Evidence map›Paper›PMID 32737460›Full record

ReviewNature reviews. Gastroenterology & hepatology2020

Parkinson disease and the gut: new insights into pathogenesis and clinical relevance.

R Alberto Travagli, Kirsteen N Browning, Michael Camilleri

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Gastroenterology & hepatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed, 6 pooled it
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 6 syntheses or guidelines pooled it, 181 citations in OpenAlex.

  1. Pooled it
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  7. Review
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  10. Sigmoid volvulus, acute colonic pseudo-obstruction, and chronic megacolon in Parkinson disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
  11. Review
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  14. Enteric glia, neuropeptides, and Parkinson's: impacts of calcitonin gene-related peptide on gut alpha synuclein.American journal of physiology. Gastrointestinal and liver physiology · 2026
    Article
  15. Mechanisms and clinical implications of gut-brain interactions.The Journal of clinical investigation · 2026
    Review
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  20. Article

48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

R Alberto TravagliDepartment of Neural and Behavioral Sciences, Penn State College of Medicine, Hershey, PA, USA. rtravagli@pennstatehealth.psu.edu.ORCID http://orcid.org/0000-0003-2297-7683
Kirsteen N BrowningDepartment of Neural and Behavioral Sciences, Penn State College of Medicine, Hershey, PA, USA.ORCID http://orcid.org/0000-0002-5062-3703
Michael CamilleriClinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), Mayo Clinic, Rochester, MN, USA.
Penn State Milton S. Hershey Medical Center · USMayo Clinic in Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The classic view portrays Parkinson disease (PD) as a motor disorder resulting from loss of substantia nigra pars compacta dopaminergic neurons. Multiple studies, however, describe prodromal, non-motor dysfunctions that affect the quality of life of patients who subsequently develop PD. These prodromal dysfunctions comprise a wide array of gastrointestinal motility disorders including dysphagia, delayed gastric emptying and chronic constipation. The histological hallmark of PD - misfolded α-synuclein aggregates that form Lewy bodies and neurites - is detected in the enteric nervous system prior to clinical diagnosis, suggesting that the gastrointestinal tract and its neural (vagal) connection to the central nervous system could have a major role in disease aetiology. This Review provides novel insights on the pathogenesis of PD, including gut-to-brain trafficking of α-synuclein as well as the newly discovered nigro-vagal pathway, and highlights how vagal connections from the gut could be the conduit by which ingested environmental pathogens enter the central nervous system and ultimately induce, or accelerate, PD progression. The pathogenic potential of various environmental neurotoxicants and the suitability and translational potential of experimental animal models of PD will be highlighted and appraised. Finally, the clinical manifestations of gastrointestinal involvement in PD and medications will be discussed briefly.

Indexed as

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsBrainDisease Models, AnimalEnteric Nervous SystemGastrointestinal DiseasesGastrointestinal MicrobiomeGastrointestinal TractHumansNeurotoxinsOxidopamineParkinson DiseaseParkinson Disease, SecondaryPesticides1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineNeurotoxinsOxidopaminePesticides

Identifiers

PMID32737460
OpenAlexW3046535450

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.