Evidence map›Paper›PMID 32737401›Full record

ArticleScientific reports2020

Terpinen-4-ol and nystatin co-loaded precursor of liquid crystalline system for topical treatment of oral candidiasis.

Renata Serignoli Francisconi, Patricia Milagros Maquera-Huacho, Caroline Coradi Tonon, Giovana Maria Fioramonti Calixto, Janaína de Cássia Orlandi Sardi, Marlus Chorilli, Denise Madalena Palomari Spolidorio

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Antifungal Activity and Type of Interaction ofJournal of fungi (Basel, Switzerland) · 2023
    Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Renata Serignoli FrancisconiDepartment of Physiology and Pathology, School of Dentistry of Araraquara, Universidade Estadual Paulista, UNESP, Araraquara, SP, Brazil.
Patricia Milagros Maquera-HuachoDepartment of Physiology and Pathology, School of Dentistry of Araraquara, Universidade Estadual Paulista, UNESP, Araraquara, SP, Brazil.ORCID http://orcid.org/0000-0002-2193-9979
Caroline Coradi TononDepartment of Physiology and Pathology, School of Dentistry of Araraquara, Universidade Estadual Paulista, UNESP, Araraquara, SP, Brazil.ORCID http://orcid.org/0000-0003-0058-9970
Giovana Maria Fioramonti CalixtoDepartment of Drugs and Medicines, School of Pharmaceutical of Araraquara, UNESP, Araraquara, SP, Brazil.ORCID http://orcid.org/0000-0003-1041-5835
Janaína de Cássia Orlandi SardiDepartment of Physiological Sciences, School of Dentistry of Piracicaba, UNICAMP, Piracicaba, SP, Brazil.ORCID http://orcid.org/0000-0002-8500-2691
Marlus ChorilliDepartment of Drugs and Medicines, School of Pharmaceutical of Araraquara, UNESP, Araraquara, SP, Brazil.ORCID http://orcid.org/0000-0002-6698-0545
Denise Madalena Palomari SpolidorioDepartment of Physiology and Pathology, School of Dentistry of Araraquara, Universidade Estadual Paulista, UNESP, Araraquara, SP, Brazil. despolidorio@gmail.com.ORCID http://orcid.org/0000-0003-2376-1024
Centro Universitário de Araraquara · BRUniversidade Estadual Paulista (Unesp) · BRUniversidade Estadual de Campinas (UNICAMP) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study was performed to develop a liquid crystalline system (LCS) incorporated with terpinen-4-ol and nystatin to evaluate its antifungal, antibiofilm, and synergistic/modulatory activity against Candida albicans. The LCS was composed of a dispersion containing 40% propoxylated and ethoxylated cetyl alcohol, 40% oleic acid, and 0.5% chitosan dispersion. According to analysis by polarized light microscopy, rheology, and mucoadhesion studies, the incorporation of 100% artificial saliva increased the pseudoplasticity, consistency index, viscosity, and mucoadhesion of the formulation. The minimum inhibitory concentration, minimum fungicidal concentration, and rate of biofilm development were used to evaluate antifungal activity; the LCS containing terpinen-4-ol and nystatin effectively inhibited C. albicans growth at a lower concentration, displaying a synergistic action. Therefore, LCS incorporated with terpinen-4-ol and nystatin is a promising alternative for preventing and treating infections and shows potential for the development of therapeutic strategies against candidiasis.

Indexed as

Candidiasis, OralAntifungal AgentsBiofilmsCandida albicansHumansNystatinTerpenesAntifungal AgentsNystatinTerpenesterpinenol-4

Identifiers

PMID32737401
PMCPMC7395782
OpenAlexW3046807271

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.