ArticleScientific reports2020
Nearly-incompressible transverse isotropy (NITI) of cornea elasticity: model and experiments with acoustic micro-tapping OCE.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed, 1 citations in OpenAlex.
- Microbubble-assisted pLIFU enhances riboflavin delivery and corneal cross-linking in an in vivo rabbit keratoconus-like model.Ultrasonics sonochemistry · 2026Article
- Multi-frequency asynchronous optical coherence elastography by direct demodulation.Biomedical optics express · 2026Article
- Biomechanical assessments of high-fluence corneal cross-linking with supplemental oxygen using optical coherence elastography inJournal of biomedical optics · 2026Article
- Phantoms for use in optical coherence elastography.Journal of biomedical optics · 2026Review
- Dual Optical Elastography Techniques Reveal the Regulation of Corneal Stiffness by Collagen XIV.Journal of biophotonics · 2026Article
- Air-Coupled Ultrasonic Optical Coherence Elastography Reveals Protocol-Dependent Corneal Stiffening in Epi-On and Epi-Off Riboflavin Crosslinking.Translational vision science & technology · 2026Article
- Mechanobiology of the tumor microenvironment: a review of therapeutic interactions and in vitro elasticity measurement techniques.Journal of biomedical science · 2026Review
- Shear Wave Optical Coherence Elastography and Structural Analysis of the Postnatal Mouse Cornea through Development.Journal of biophotonics · 2025Article
- Reconstruction of tensile and shear elastic moduli in anisotropic nearly incompressible media using Rayleigh wave phase and group velocities.Journal of biomedical optics · 2025Article
- Optical Coherence Elastography Measures Mechanical Tension in the Lens and Capsule.Acta biomaterialia · 2025Article
- Finite Element Model of the Effect of Optic Nerve Sheath Anisotropy on Ocular Loading During Horizontal Duction.Bioengineering (Basel, Switzerland) · 2025Article
- Determinants of Human Corneal Mechanical Wave Dispersion for In Vivo Optical Coherence Elastography.Translational vision science & technology · 2025Article
- Parameterization of the stress-strain relation for modeling wave propagation in nearly incompressible transversely isotropic materials.The Journal of the Acoustical Society of America · 2024Article
- Chirp excitation for natural frequency optical coherence elastography.Biomedical optics express · 2024Article
- Revealing regional variations in scleral shear modulus in a rabbit eye model using multi-directional ultrasound optical coherence elastography.Scientific reports · 2024Article
- Effects of Different Scleral Photo-Crosslinking Modalities on Scleral Stiffness and Hydration.Investigative ophthalmology & visual science · 2024Article
- In Vivo Optical Coherence Elastography Unveils Spatial Variation of Human Corneal Stiffness.IEEE transactions on bio-medical engineering · 2024Article
- Acute alcohol consumption modulates corneal biomechanical properties as revealed by optical coherence elastography.Journal of biomechanics · 2024Article
- In Vivo Evaluation of Corneal Biomechanics Following Cross-Linking Surgeries Using Optical Coherence Elastography in a Rabbit Model of Keratoconus.Translational vision science & technology · 2024Article
- Simultaneous tensile and shear measurement of the human cornea in vivo using S0- and A0-wave optical coherence elastography.Acta biomaterialia · 2024Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The cornea provides the largest refractive power for the human visual system. Its stiffness, along with intraocular pressure (IOP), are linked to several pathologies, including keratoconus and glaucoma. Although mechanical tests can quantify corneal elasticity ex vivo, they cannot be used clinically. Dynamic optical coherence elastography (OCE), which launches and tracks shear waves to estimate stiffness, provides an attractive non-contact probe of corneal elasticity. To date, however, OCE studies report corneal moduli around tens of kPa, orders-of-magnitude less than those (few MPa) obtained by tensile/inflation testing. This large discrepancy impedes OCE's clinical adoption. Based on corneal microstructure, we introduce and fully characterize a nearly-incompressible transversely isotropic (NITI) model depicting corneal biomechanics. We show that the cornea must be described by at least two shear moduli, contrary to current single-modulus models, decoupling tensile and shear responses. We measure both as a function of IOP in ex vivo porcine cornea, obtaining values consistent with both tensile and shear tests. At pressures above 30 mmHg, the model begins to fail, consistent with non-linear changes in cornea at high IOP.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.