Trial reportScientific reports2020
Detrended fluctuation analysis of gait dynamics when entraining to music and metronomes at different tempi in persons with multiple sclerosis.
Trial report in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Potential benefits of music-based therapies on rehabilitation outcomes in people with multiple sclerosis: a systematic review.BMJ open · 2026Pooled it
- Temporal prediction and feedforward control in cerebellar ataxia during spontaneous, instructed, and adaptive auditory-motor coupling while walking.Scientific reports · 2025Article
- Preserved auditory-motor synchronization during finger-tapping to music and metronomes at various tempi in progressive multiple sclerosis.Frontiers in neurology · 2025Article
- How Gait Nonlinearities in Individuals Without Known Pathology Describe Metabolic Cost During Walking Using Artificial Neural Network and Multiple Linear Regression.Applied sciences (Basel, Switzerland) · 2024Article
- Interlimb Coordination and Auditory-Motor Synchronization in Children with Developmental Coordination Disorder: Examining Antiphase Knee Movements with Auditory Metronomes While Seated.Children (Basel, Switzerland) · 2024Article
- Feature derivation and classification of auditory-motor coupling dynamics in healthy and neurologically impaired adults.PloS one · 2024Article
- Association between Self-reported Sleep Quality and Single-task Gait in Young Adults: A Study Using Machine Learning.Sleep science (Sao Paulo, Brazil) · 2023Article
- Association between Self-Reported Prior Night's Sleep and Single-Task Gait in Healthy, Young Adults: A Study Using Machine Learning.Sensors (Basel, Switzerland) · 2022Article
- Neural Entrainment Meets Behavior: The Stability Index as a Neural Outcome Measure of Auditory-Motor Coupling.Frontiers in human neuroscience · 2021Article
- Rhythm and Music-Based Interventions in Motor Rehabilitation: Current Evidence and Future Perspectives.Frontiers in human neuroscience · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In persons with multiple sclerosis (PwMS), synchronizing walking to auditory stimuli such as to music and metronomes have been shown to be feasible, and positive clinical effects have been reported on step frequency and perception of fatigue. Yet, the dynamic interaction during the process of synchronization, such as the coupling of the steps to the beat intervals in music and metronomes, and at different tempi remain unknown. Understanding these interactions are clinically relevant, as it reflects the pattern of step intervals over time, known as gait dynamics. 28 PwMS and 29 healthy controls were instructed to walk to music and metronomes at 6 tempi (0-10% in increments of 2%). Detrended fluctuation analysis was applied to calculate the fractal statistical properties of the gait time-series to quantify gait dynamics by the outcome measure alpha. The results showed no group differences, but significantly higher alpha when walking to music compared to metronomes, and when walking to both stimuli at tempi + 8, + 10% compared to lower tempi. These observations suggest that the precision and adaptation gain differ during the coupling of the steps to beats in music compared to metronomes (continuous compared to discrete auditory structures) and at different tempi (different inter-beat-intervals).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.