SynthesisScientific reports2020
Vitamin D supplementation effects on the clinical outcomes of patients with coronary artery disease: a systematic review and meta-analysis.
Synthesis in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- The Effect of Vitamin D Supplementation on Lipid Profiles: an Umbrella Review of Meta-Analyses.Advances in nutrition (Bethesda, Md.) · 2023Pooled it
- Predictive value of 25-hydroxyvitamin D level in patients with coronary artery disease: A meta-analysis.Frontiers in nutrition · 2022Pooled it
- The Influence of Vitamin D Intake and Status on Mental Health in Children: A Systematic Review.Nutrients · 2021Pooled it
- Emerging Prognostic Risk Factors in Acute Coronary Syndromes: Beyond Traditional Risk Assessment.Journal of clinical medicine · 2026Review
- Article
- HDL-C as a potential mediator between serum 25(OH)D and the angiographic severity of coronary artery disease: a single-center cross-sectional study.Clinics (Sao Paulo, Brazil) · 2026Article
- Article
- Article
- Recent Updates and Advances in the Association Between Vitamin D Deficiency and Risk of Thrombotic Disease.Nutrients · 2024Review
- The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial.Advanced biomedical research · 2024Article
- Assessing the relative importance of vitamin D deficiency in cardiovascular health.Frontiers in cardiovascular medicine · 2024Article
- Vitamin D and Cardiovascular Diseases: An Update.Cureus · 2023Review
- The Mutual Interplay between Bone, Glucose and Lipid Metabolism: The Role of Vitamin D and PTH.Nutrients · 2023Article
- Vitamin D Determinants, Status, and Antioxidant/Anti-inflammatory-Related Effects in Cardiovascular Risk and Disease: Not the Last Word in the Controversy.Antioxidants (Basel, Switzerland) · 2023Review
- Impact of vitamin D receptor gene polymorphisms (TaqI and BsmI) on the incidence and severity of coronary artery disease: a report from southern Iran.BMC cardiovascular disorders · 2023Article
- Article
- Vitamin D and cardiovascular disease risk. A literature overview.Molecular biology reports · 2022Review
- Vitamin D, infections and immunity.Reviews in endocrine & metabolic disorders · 2022Review
- The Effects of Vitamin D on Immune System and Inflammatory Diseases.Biomolecules · 2021Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this systematic review and meta-analysis our aim was to assess the effect of vitamin D supplementation on cardiac outcomes in patients with coronary artery disease (CAD). The search terms were performed from January 2000 to January 2018, only randomized clinical trials (RCT) in human subjects were considered, with no language restrictions. The electronic databases used in this study were: PubMed; Cochran library; Embase; and Scopus. Two independent expert reviewers carried out data extraction according to Cochrane recommendations. Only four RCTs were found in relation to the effects of vitamin D supplementation on the coronary artery disease. In these 299 patients, vitamin D supplementation had significant favorable effects on Diastolic Blood Pressure (DBP) (- 2.96, p = 0.02) and Parathyroid hormone (PTH) (- 4.05, p < 0.001). However, it had no significant effects on hs-CRP mean difference (- 0.04, p = 0.25), total cholesterol (TC) (- 0.46, p = 0.83), triglyceride (TG) (0.68, p = 0.89), low-density lipoproteins (LDL) (2.08, p = 0.56), and high-density lipoproteins (HDL) (- 2.59, p = 0.16). In conclusion, the use of vitamin D was associated with improvements in some cardiac outcomes of CAD patients with vitamin D deficiency. Also, further research is needed to clarify these results.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.