Evidence map›Paper›PMID 32737313›Full record

ArticleNature communications2020

Structures of the human mitochondrial ribosome bound to EF-G1 reveal distinct features of mitochondrial translation elongation.

Ravi Kiran Koripella, Manjuli R Sharma, Kalpana Bhargava, Partha P Datta, Prem S Kaushal, Pooja Keshavan, Linda L Spremulli, Nilesh K Banavali, Rajendra K Agrawal

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. HflX-mediated drug resistance through ribosome splitting and rRNA disordering in mycobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Translation in Mitochondrial Ribosomes.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  19. Assembly of the Mitochondrial Translation Initiation Complex.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  20. The Structural Dynamics of Translation.Annual review of biochemistry · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Ravi Kiran Koripella *Division of Translational Medicine, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY, 12201, USA.ORCID http://orcid.org/0000-0003-2901-1507
Manjuli R Sharma *Division of Translational Medicine, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY, 12201, USA.ORCID http://orcid.org/0000-0003-4821-748X
Kalpana BhargavaDepartment of Chemistry, Campus Box 3290, University of North Carolina, Chapel Hill, NC, USA.
Partha P DattaDivision of Translational Medicine, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY, 12201, USA.
Prem S KaushalDivision of Translational Medicine, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY, 12201, USA.
Pooja KeshavanDivision of Translational Medicine, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY, 12201, USA.
Linda L SpremulliDepartment of Chemistry, Campus Box 3290, University of North Carolina, Chapel Hill, NC, USA.
Nilesh K BanavaliDivision of Translational Medicine, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY, 12201, USA.ORCID http://orcid.org/0000-0003-2206-7049
Rajendra K AgrawalDivision of Translational Medicine, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY, 12201, USA. rajendra.agrawal@health.ny.gov.ORCID http://orcid.org/0000-0001-9392-0065
New York State Department of Health · USUniversity of North Carolina at Chapel Hill · USIndian Institute of Science Education and Research Kolkata · IN

Funding

ZWITTERION SURFACTANT DDMAB FOR IMPROV STABIL OF PROTEINP41RR001209 · NCRR · STANFORD UNIVERSITY · PI GONZALEZ, ANA M · 1985 to 2011
$38.9M
TRD #3: An automated and streamlined pipeline for in-situ molecular microscopyP41GM103310 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2012 to 2021
$14.7M
Structural Aspects of Protein Synthesis in the Mammalian MitochondriaR01GM061576 · NIGMS · WADSWORTH CENTER · PI AGRAWAL, RAJENDRA K · 2001 to 2018
$6.4M
NCRR NIH HHS P41 RR001209NIGMS NIH HHS P41 GM103310NIGMS NIH HHS R01 GM061576
6 · The paper itself

Abstract

The mammalian mitochondrial ribosome (mitoribosome) and its associated translational factors have evolved to accommodate greater participation of proteins in mitochondrial translation. Here we present the 2.68-3.96 Å cryo-EM structures of the human 55S mitoribosome in complex with the human mitochondrial elongation factor G1 (EF-G1

Indexed as

Peptide Chain Elongation, TranslationalAmino Acid SequenceBinding SitesCryoelectron MicroscopyHEK293 CellsHumansMitochondriaMitochondrial MembranesMitochondrial ProteinsModels, MolecularNucleic Acid ConformationPeptide Elongation Factor GProtein BindingProtein Conformation, alpha-HelicalProtein Conformation, beta-StrandProtein Interaction Domains and MotifsGFM1 protein, humanMitochondrial ProteinsPeptide Elongation Factor GRecombinant ProteinsRibosomal ProteinsRNA, MitochondrialRNA, Transfer

Identifiers

PMID32737313
PMCPMC7395135
OpenAlexW3046592835

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.