Evidence map›Paper›PMID 32737120›Full record

ArticleGenetics2020

Promoter Proximal Pausing Limits Tumorous Growth Induced by the Yki Transcription Factor in

Sanket Nagarkar, Ruchi Wasnik, Pravallika Govada, Stephen Cohen, L S Shashidhara

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Science advances · 2023
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Sanket NagarkarIndian Institute of Science Education and Research (IISER), Pashan, Pune 411008.
Ruchi WasnikIndian Institute of Science Education and Research (IISER), Pashan, Pune 411008.
Pravallika GovadaIndian Institute of Science Education and Research (IISER), Pashan, Pune 411008.
Stephen CohenDepartment of Cellular and Molecular Medicine, University of Copenhagen, 2200N, Denmark.
L S ShashidharaIndian Institute of Science Education and Research (IISER), Pashan, Pune 411008.ORCID 0000-0001-9306-1432
Indian Institute of Science Education and Research Pune · INAshoka University · INUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Promoter proximal pausing (PPP) of RNA polymerase II has emerged as a crucial rate-limiting step in the regulation of gene expression. Regulation of PPP is brought about by complexes 7SK snRNP, P-TEFb (Cdk9/cycT), and the negative elongation factor (NELF), which are highly conserved from

Indexed as

Gene Expression Regulation, NeoplasticPromoter Regions, GeneticAnimalsCarcinogenesisCyclin-Dependent Kinase 9Drosophila melanogasterDrosophila ProteinsImaginal DiscsMethyltransferasesNuclear ProteinsRNA-Binding ProteinsTrans-ActivatorsWings, AnimalYAP-Signaling Proteinsbicoid-interacting protein 3, DrosophilaCyclin-Dependent Kinase 9Drosophila ProteinsHEXIM protein, DrosophilaMethyltransferasesNuclear ProteinsRNA-Binding ProteinsTrans-ActivatorsYAP-Signaling ProteinsYki protein, DrosophilaDrosophilaHippo pathwaypromoter proximal pausingtranscription regulation in growth and cancertumorigenesis

Identifiers

PMID32737120
PMCPMC7463282
OpenAlexW3046888881

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.