Evidence map›Paper›PMID 32737087›Full record

ArticleBMJ open2020

Open-label, multicentre, single-arm trial of monthly injections of depot buprenorphine in people with opioid dependence: protocol for the CoLAB study.

Briony Larance, Marianne Byrne, Nicholas Lintzeris, Suzanne Nielsen, Jason Grebely, Louisa Degenhardt, Jeyran Shahbazi, Marian Shanahan, Kari Lancaster, Gregory Dore and 3 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03809143 (An Open-label, Multicentre, Single-arm Trial of Monthly Injections of Depot Buprenorphine in People With Opioid Dependence), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03809143 phase3unknown statusnot on this map

An Open-label, Multicentre, Single-arm Trial of Monthly Injections of Depot Buprenorphine in People With Opioid Dependence

TypeinterventionalSponsorThe University of New South WalesRan2019 to 2021Enrolled100ConditionsOpioid DependenceArmsRBP-6000
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 4 countries.

Briony LaranceNational Drug and Alcohol Research Centre, UNSW Sydney, Sydney, New South Wales, Australia.
Marianne ByrneNational Drug and Alcohol Research Centre, UNSW Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-3489-2532
Nicholas LintzerisDiscipline of Addiction Medicine, University of Sydney, Surry Hills, New South Wales, Australia.
Suzanne NielsenNational Drug and Alcohol Research Centre, UNSW Sydney, Sydney, New South Wales, Australia.ORCID 0000-0001-5341-1055
Jason GrebelyThe Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.
Louisa DegenhardtNational Drug and Alcohol Research Centre, UNSW Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-8513-2218
Jeyran ShahbaziNational Drug and Alcohol Research Centre, UNSW Sydney, Sydney, New South Wales, Australia.
Marian ShanahanNational Drug and Alcohol Research Centre, UNSW Sydney, Sydney, New South Wales, Australia.ORCID 0000-0001-9873-3576
Kari LancasterCentre for Social Research in Health, UNSW Sydney, Sydney, New South Wales, Australia.
Gregory DoreThe Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.
Robert AliNational Drug and Alcohol Research Centre, UNSW Sydney, Sydney, New South Wales, Australia.
Michael FarrellNational Drug and Alcohol Research Centre, UNSW Sydney, Sydney, New South Wales, Australia michael.farrell@unsw.edu.au.
CoLAB study team
UNSW Sydney · AUThe University of Melbourne · AUThe University of Sydney · AUUniversity of Wollongong · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionOpioid agonist treatment is effective for opioid dependence and newer extended-release buprenorphine (BUP-XR) injections represent a significant development. The Community Long-Acting Buprenorphine (CoLAB) study aims to evaluate client outcomes among people with opioid dependence receiving 48 weeks of BUP-XR treatment, and examines the implementation of BUP-XR in diverse community healthcare settings in Australia. METHODS AND ANALYSIS: The CoLAB study is a prospective single-arm, multicentre, open-label trial of monthly BUP-XR injections in people with opioid dependence. Participants are being recruited from a network of general practitioner and specialist drug treatment services located in the states of New South Wales, Victoria and South Australia in Australia. Following a minimum 7 days on 8-32 mg of sublingual buprenorphine (±naloxone), participants will receive monthly subcutaneous BUP-XR injections administered by a healthcare practitioner at intervals of 28 days (-2/+14 days). The primary endpoint is participant retention in treatment at 48 weeks after treatment initiation. Secondary endpoints will evaluate dosing schedule variations, craving, withdrawal, substance use, health and well-being, and client-reported treatment experience. Qualitative and costing substudies will examine implementation barriers and facilitators at the client and provider level. ETHICS AND DISSEMINATION: The study has received ethics approval from the St Vincent's Hospital Sydney Human Research Ethics Committee (Ref. HREC/18/SVH/221). The findings will be disseminated via publication in peer-reviewed journals, presentations at national and international scientific conferences, and in relevant community organisation publications and forums. TRIAL REGISTRATION NUMBER: NCT03809143 PROTOCOL IDENTIFIER: CoLAB1801, V.4.0 dated 01 August 2019.

Indexed as

BuprenorphineOpioid-Related DisordersHumansMulticenter Studies as TopicNarcotic AntagonistsNew South WalesProspective StudiesSouth AustraliaVictoriaBuprenorphineNarcotic Antagonistsbuprenorphinedrug dependenceextended release formulationopiate medication-assisted treatmentopioid dependence

Identifiers

PMID32737087
PMCPMC7398105
OpenAlexW3046711279

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.