Evidence map›Paper›PMID 32736919›Full record

ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2021

Subjective Cognitive Complaints Given in Questionnaire: Relationship With Brain Structure, Cognitive Performance and Self-Reported Depressive Symptoms in a 25-Year Retrospective Cohort Study.

Anya Topiwala, Sana Suri, Charlotte Allan, Enikő Zsoldos, Nicola Filippini, Claire E Sexton, Abda Mahmood, Archana Singh-Manoux, Clare E Mackay, Mika Kivimäki and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Anya TopiwalaDepartment of Psychiatry (AT, SS, CA,EZ, NF, CES, AM, CEM, KPE), University of Oxford, Oxford, UK; Big Data Institute (AT), University of Oxford, Oxford, UK. Electronic address: anya.topiwala@bdi.ox.ac.uk.
Sana SuriDepartment of Psychiatry (AT, SS, CA,EZ, NF, CES, AM, CEM, KPE), University of Oxford, Oxford, UK; Wellcome Centre for Integrative Neuroimaging (SS, EZ, NF, CES, CEM), Oxford, UK.
Charlotte AllanDepartment of Psychiatry (AT, SS, CA,EZ, NF, CES, AM, CEM, KPE), University of Oxford, Oxford, UK; Institute of Translational and Clinical Research (CA), Newcastle University/Cumbria, Northumberland, Tyne and Wear NHS Foundation Trust, UK.
Enikő ZsoldosDepartment of Psychiatry (AT, SS, CA,EZ, NF, CES, AM, CEM, KPE), University of Oxford, Oxford, UK; Wellcome Centre for Integrative Neuroimaging (SS, EZ, NF, CES, CEM), Oxford, UK.
Nicola FilippiniDepartment of Psychiatry (AT, SS, CA,EZ, NF, CES, AM, CEM, KPE), University of Oxford, Oxford, UK; Wellcome Centre for Integrative Neuroimaging (SS, EZ, NF, CES, CEM), Oxford, UK.
Claire E SextonDepartment of Psychiatry (AT, SS, CA,EZ, NF, CES, AM, CEM, KPE), University of Oxford, Oxford, UK; Wellcome Centre for Integrative Neuroimaging (SS, EZ, NF, CES, CEM), Oxford, UK; Global Brain Health Institute, Memory and Aging Center, Department of Neurology (CES), University of California, San Francisco.
Abda MahmoodDepartment of Psychiatry (AT, SS, CA,EZ, NF, CES, AM, CEM, KPE), University of Oxford, Oxford, UK.
Archana Singh-ManouxUniversité de Paris (ASM), INSERM U1153, Paris, France; Department of Epidemiology and Public Health (ASM, MK), University College London, London, UK.
Clare E MackayDepartment of Psychiatry (AT, SS, CA,EZ, NF, CES, AM, CEM, KPE), University of Oxford, Oxford, UK; Wellcome Centre for Integrative Neuroimaging (SS, EZ, NF, CES, CEM), Oxford, UK.
Mika KivimäkiDepartment of Epidemiology and Public Health (ASM, MK), University College London, London, UK.
Klaus P EbmeierDepartment of Psychiatry (AT, SS, CA,EZ, NF, CES, AM, CEM, KPE), University of Oxford, Oxford, UK.
University of Oxford · GBWellcome Centre for Integrative Neuroimaging · GBInserm · FRUniversity College London · GBUniversity of California, San Francisco · US

Funding

Education, socioeconomic status and Aging: transitions from multimorbidity to functional limitations and mortalityR01AG056477 · NIA · UNIVERSITY COLLEGE LONDON · PI KIVIMAKI, MIKA J, SINGH-MANOUX, ARCHANA · 2018 to 2022
$2.8M
Health behaviors over the adult lifecourse and cognitive agingR01AG034454 · NIA · UNIVERSITY COLLEGE LONDON · PI KIVIMAKI, MIKA J, SINGH-MANOUX, ARCHANA · 2009 to 2013
$1.5M
Role of mid- and late-life risk factors in social inequalities in Alzheimer's Disease and Related DementiasRF1AG062553 · NIA · INSERM PARIS 5 · PI KIVIMAKI, MIKA J, SINGH-MANOUX, ARCHANA · 2019 to 2019
$1.5M
Medical Research Council G1001354Medical Research Council MC_EX_MR/N50192X/1Medical Research Council MR/K013351/1Medical Research Council MR/L023784/1Medical Research Council MR/M024962/1Medical Research Council MR/R024227/1Medical Research Council MR/S011676/1NIA NIH HHS R01 AG034454NIA NIH HHS R01 AG056477NIA NIH HHS RF1 AG062553Parkinson's UK J-0901Wellcome Trust
6 · The paper itself

Abstract

backgroundSubjective cognitive complaints are common but it is unclear whether they indicate an underlying pathological process or reflect affective symptoms.

method800 community-dwelling older adults were drawn from the Whitehall II cohort. Subjective cognitive complaint inquiry for memory and concentration, a range of neuropsychological tests and multimodal MRI were performed in 2012-2016. Subjective complaints were again elicited after 1 year. Group differences in grey and white matter, between those with and without subjective complaints, were assessed using voxel-based morphometry and tract-based spatial statistics, respectively. Mixed effects models assessed whether cognitive decline or depressive symptoms (over a 25-year period) were associated with later subjective complaints. Analyses were controlled for potential confounders and multiple comparisons.

resultsMean age of the sample at scanning was 69.8 years (±5.1, range: 60.3-84.6). Subjective memory complaints were common (41%) and predicted further similar complaints later (mean 1.4 ± 1.4 years). There were no group differences in grey matter density or white matter integrity. Subjective complaints were not cross-sectionally or longitudinally associated with objectively assessed cognition. However, those with subjective complaints reported higher depressive symptoms ("poor concentration": odds ratio = 1.12, 95% CI 1.07-1.18; "poor memory": odds ratio = 1.18, 1.12-1.24).

conclusionsIn our sample subjective complaints were consistent over time and reflected depressive symptoms but not markers of neurodegenerative brain damage or concurrent or future objective cognitive impairment. Clinicians assessing patients presenting with memory complaints should be vigilant for affective disorders. These results question the rationale for including subjective complaints in a spectrum with Mild Cognitive Impairment diagnostic criteria.

Indexed as

CognitionHealth SurveysSelf ReportAgedAged, 80 and overBrainCognitive DysfunctionDepressionFemaleGray MatterHumansMaleMemory DisordersNeuropsychological TestsRetrospective StudiesWhite Matterbrain structuredepressionneuroimagingSubjective memory

Identifiers

PMID32736919
PMCPMC8097240
OpenAlexW3038427562

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.