Evidence map›Paper›PMID 32736645›Full record

ArticleMolecular brain2020

Alleviating toxic α-Synuclein accumulation by membrane depolarization: evidence from an in vitro model of Parkinson's disease.

Alysia Ross, Viktoria Xing, Ting Ting Wang, Samantha C Bureau, Giovana A Link, Teresa Fortin, Hui Zhang, Shawn Hayley, Hongyu Sun

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular brain, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

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  7. Frontiers in neuroscience · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Alysia RossDepartment of Neuroscience, Carleton University, Ottawa, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada.
Viktoria XingDepartment of Neuroscience, Carleton University, Ottawa, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada.
Ting Ting WangDepartment of Neuroscience, Carleton University, Ottawa, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada.
Samantha C BureauDepartment of Neuroscience, Carleton University, Ottawa, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada.
Giovana A LinkDepartment of Neuroscience, Carleton University, Ottawa, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada.
Teresa FortinDepartment of Neuroscience, Carleton University, Ottawa, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada.
Hui ZhangDepartment of Neurology, SUNY Downstate Medical center, Brooklyn, NY, 11226, USA.
Shawn HayleyDepartment of Neuroscience, Carleton University, Ottawa, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada. Shawn.Hayley@carleton.ca.
Hongyu SunDepartment of Neuroscience, Carleton University, Ottawa, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada. Hongyu.sun@carleton.ca.ORCID 0000-0003-2590-9803
Carleton University · CASUNY Downstate Health Sciences University · USUniversity of Ottawa · CA

Funding

CIHR
6 · The paper itself

Abstract

Parkinson's disease (PD) is characterized by the formation of toxic, fibrillar form alpha-synuclein (α-Syn) protein aggregates in dopaminergic neurons. Accumulating evidence has shown a multifactorial interplay between the intracellular calcium elevation and α-Syn dynamics. However, whether membrane depolarization regulates toxic α-Syn aggregates remains unclear. To understand this better, we used an in vitro α-Syn preformed fibrils (PFF) model of PD in human neural cells. We demonstrated functional membrane depolarization in differentiated SH-SY5Y cells induced by two independent treatments: high extracellular K

Indexed as

Models, Biologicalalpha-SynucleinAmyloidCell DeathCell DifferentiationCell Line, TumorElectric StimulationHumansMembrane PotentialsParkinson DiseasePicrotoxinPotassium Chloridealpha-SynucleinAmyloidPicrotoxinPotassium ChlorideCalcium channelDirect current stimulationGABAA receptorMembrane depolarizationParkinson’s diseasePreformed fibrilsα-Synuclein

Identifiers

PMID32736645
PMCPMC7395353
OpenAlexW3046410837

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.