Evidence map›Paper›PMID 32736620›Full record

ArticleBMC pulmonary medicine2020

Lung-protective ventilation suppresses systemic and hepatic vein levels of cell-free DNA in porcine experimental post-operative sepsis.

Axel Nyberg, Alexander Larsson, Juulia Jylhävä, Mikko Hurme, Jesper Sperber, Miklós Lipcsey, Markus Castegren

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pulmonary medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Axel NybergDepartment of Anaesthesiology & Intensive Care, Centre for Clinical Research, Sörmland, Uppsala University, Mälarsjukhuset, SE-631 88 Eskilstuna, Uppsala, Sweden. axel.nyberg@regionsormland.se.ORCID http://orcid.org/0000-0002-8062-5347
Alexander LarssonCentre for Clinical Research, Region of Västmanland, Uppsala University, Uppsala, Sweden.
Juulia JylhäväDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Mikko HurmeFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Jesper SperberDepartment of Anaesthesiology & Intensive Care, Centre for Clinical Research, Sörmland, Uppsala University, Mälarsjukhuset, SE-631 88 Eskilstuna, Uppsala, Sweden.
Miklós LipcseyHedenstierna laboratory, CIRRUS, Anesthesiology and Intensive Care, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Markus CastegrenDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Uppsala University · SEKarolinska Institutet · SETampere University · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPlasma levels of cell-free DNA (cf-DNA) are known to be elevated in sepsis and high levels are associated with a poor prognosis. Mechanical ventilation affects systemic inflammation in which lung-protective ventilation attenuates the inflammatory response. The aim was to study the effect of a lung protective ventilator regime on arterial and organ-specific venous blood as well as on trans-organ differences in cf-DNA levels in a porcine post-operative sepsis model.

methodOne group of anaesthetised, domestic-breed, 9-12 weeks old, pigs were ventilated with protective ventilation (V

resultsThe protective ventilation group had lower levels of cf-DNA in arterial (p = 0.02) and hepatic venous blood (p = 0.03) compared with the controls. Transhepatic differences in cf-DNA were lower in the protective group, compared with the controls (p = 0.03). No differences between the groups were noted as regards the transcerebral, transsplanchnic or the transpulmonary cf-DNA differences.

conclusionsProtective ventilation suppresses arterial levels of cf-DNA. The liver seems to be a net contributor to the systemic cf-DNA levels, but this effect is attenuated by protective ventilation.

Indexed as

Respiration, ArtificialAnimalsCell-Free Nucleic AcidsCytokinesDisease Models, AnimalFemaleHepatic VeinsInflammationMalePeak Expiratory Flow RatePortal VeinPostoperative ComplicationsSepsisSwineTidal VolumeCell-Free Nucleic AcidsCytokinesCytokinesEndotoxinInnate immunityIntensive careLow tidal volume ventilation

Identifiers

PMID32736620
PMCPMC7393331
OpenAlexW3046236731

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.