Evidence map›Paper›PMID 32736591›Full record

ArticleFluids and barriers of the CNS2020

Chronic extradural compression of spinal cord leads to syringomyelia in rat model.

Longbing Ma, Qingyu Yao, Can Zhang, Mo Li, Lei Cheng, Fengzeng Jian

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Fluids and barriers of the CNS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

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  12. A novel classification and its clinical significance in Chiari I malformation with syringomyelia based on high-resolution MRI.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Longbing MaDepartment of Neurosurgery, China International Neuroscience Institute, Xuanwu Hospital, Capital Medical University, 45 Changchu Street, Beijing, 100053, China.
Qingyu YaoDepartment of Neurosurgery, China International Neuroscience Institute, Xuanwu Hospital, Capital Medical University, 45 Changchu Street, Beijing, 100053, China.
Can ZhangDepartment of Neurosurgery, China International Neuroscience Institute, Xuanwu Hospital, Capital Medical University, 45 Changchu Street, Beijing, 100053, China.
Mo LiCell Therapy Center, Xuanwu Hospital, Capital Medical University, Beijing, China.
Lei ChengDepartment of Neurosurgery, China International Neuroscience Institute, Xuanwu Hospital, Capital Medical University, 45 Changchu Street, Beijing, 100053, China.
Fengzeng JianDepartment of Neurosurgery, China International Neuroscience Institute, Xuanwu Hospital, Capital Medical University, 45 Changchu Street, Beijing, 100053, China. jianfengzeng@xwh.ccmu.edu.com.
Capital Medical University · CNChinese Institute for Brain Research · CN

Funding

Beijing Postdoctoral Research Foundation ZZ2019-17Postdoctoral Research Foundation of China 2018M641412
6 · The paper itself

Abstract

backgroundSyringomyelia is a common spinal cord lesion. However, whether CSF blockage is linked to the formation and enlargement of syringomyelia is still controversial. The current model of syringomyelia needs modification to more closely mimic the clinical situation.

methodsWe placed cotton strips under the T13 lamina of 40 8-week-old rats and blocked CSF flow by extradural compression. After 4 and 8 weeks, MRI was performed to evaluate the morphology of syringomyelia and the ratio of spinal cord diameter to syrinx diameter calculated. Locomotor function was evaluated weekly. Spinal cord sections, staining and immunohistochemistry were performed 8 weeks after surgery, the ratio of the central canal to the spinal cord area was calculated, and ependymal cells were counted. In another experiment, we performed decompression surgery for 8 rats with induced syringomyelia at the 8th week after surgery. During the surgery, the cotton strip was completely removed without damaging the dura mater. Then, the rats received MRI imaging during the following weeks and were sacrificed for pathological examination at the end of the experiment.

resultsSyringomyelia formed in 82.5% (33/40) of rats at the 8-week follow-up. The Basso, Beattie and Bresnahan (BBB) scores of rats in the experimental group decreased from 21.0±0.0 to 18.0 ±3.9 in the first week after operation but returned to normal in later weeks. The BBB score indicated that the locomotor deficit caused by compression is temporary and can spontaneously recover. MRI showed that the syrinx is located in the center of the spinal cord, which is very similar to the most common syringomyelia in humans. The ratio of the central canal to the spinal cord area reached (2.9 ± 2.0) × 10

conclusionExtradural blockade of CSF flow can induce syringomyelia in rats. Temporary locomotor deficit occurred in some rats. This reproducible rat model of syringomyelia, which mimics syringomyelia in humans, can provide a good model for the study of disease mechanisms and therapies.

Indexed as

Disease Models, AnimalAnimalsFemaleLocomotionRats, Sprague-DawleySpinal CordSpinal Cord CompressionSyringomyeliaCentral canalCSFExtradural compressionRat modelSyringomyelia

Identifiers

PMID32736591
PMCPMC7393857
OpenAlexW3046534852

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.