Evidence map›Paper›PMID 32736586›Full record

ArticleJournal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale2020

Characteristics of velopharyngeal dysfunction in 22q11.2 deletion syndrome: a retrospective case-control study.

Sebastiano Failla, Peng You, Chandheeb Rajakumar, Anne Dworschak-Stokan, Philip C Doyle, Murad Husein

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Otolaryngologic disease in 22q11.2 deletion syndrome: spectrum, co-occurrence, and outcomes in a contemporary pediatric cohort.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sebastiano FaillaVoice Production and Perception Laboratory, Rehabilitation Sciences, Western University, London, Ontario, Canada.
Peng YouDepartment of Otolaryngology-Head and Neck Surgery, Children's Hospital, London Health Sciences Center, Western University - Schulich School of Medicine, Victoria Campus, 800 Commissioners Road East, London, ON, N6A 5W9, Canada.
Chandheeb RajakumarDepartment of Otolaryngology-Head and Neck Surgery, Children's Hospital, London Health Sciences Center, Western University - Schulich School of Medicine, Victoria Campus, 800 Commissioners Road East, London, ON, N6A 5W9, Canada.
Anne Dworschak-StokanThames Valley Children's Centre, London, Ontario, Canada.
Philip C DoyleVoice Production and Perception Laboratory, Department of Otolaryngology-Head and Neck Surgery, Western University, London, Ontario, Canada.
Murad HuseinDepartment of Otolaryngology-Head and Neck Surgery, Children's Hospital, London Health Sciences Center, Western University - Schulich School of Medicine, Victoria Campus, 800 Commissioners Road East, London, ON, N6A 5W9, Canada. Murad.Husein@lhsc.on.ca.ORCID http://orcid.org/0000-0002-0805-2644
Western University · CAThames Valley Children's Centre · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo identify and describe the dynamic features of velopharyngeal dysfunction (VPD) in patients with 22q11.2 deletion syndrome relative to patients with non-syndromic cleft palates. STUDY

designRetrospective case-control study.

settingPediatric tertiary care center. SUBJECTS AND

methodsA total of 30 children (aged 9-16 years) with VPD were included in this study. Fifteen children with a definitive diagnosis of 22q11.2 deletion syndrome requiring surgical VPD repair were included in the 22q11.2 deletion syndrome group. Fifteen age- and sex-matched children with non-syndromic cleft palate requiring surgical VPD repair were included in the non-syndromic cleft palate group for comparison. Velar displacement, lateral pharyngeal wall displacement, and lateral pharyngeal wall motion pattern data were extracted from preoperative Multiview Videofluoroscopy imaging studies of all children and compared across groups.

resultsLateral pharyngeal wall displacement was found to be reduced in the 22q11.2 deletion syndrome group (U = 29.50, p = .001, r = .63). However, measures of velar displacement were not observed to differ between groups. Similarly, lateral pharyngeal wall motion pattern distributions were not found to differ across these two groups.

conclusionsVelopharyngeal dysfunction in patients with 22q11.2 deletion syndrome showed differences in dynamic velopharyngeal function when compared to non-syndromic cleft palate patients. The current findings provide initial insights into the unique aspects of velopharyngeal dysfunction for patients with 22q11.2 deletion syndrome. These findings may guide further efforts directed toward understanding the dynamic velopharyngeal characteristics of this population and potentially optimize surgical management and functional outcomes.

Indexed as

AdolescentCase-Control StudiesChildCleft PalateDiGeorge SyndromeFemaleHumansMalePharynxRetrospective StudiesVelopharyngeal Insufficiency22q11.2 deletionNon-syndromic cleft palateVelopharyngeal dysfunctionVelopharyngeal insufficiency

Identifiers

PMID32736586
PMCPMC7393773
OpenAlexW3046493079

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.