ArticleCritical care (London, England)2020
Association between delirium in the intensive care unit and subsequent neuropsychiatric disorders.
Article in Critical care (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Critical care delirium: prevention, identification and management: a narrative review.Anaesthesia · 2026Review
- Early Risk Stratification of Delirium in Intermediate Care Units and Its Impact on 30-Day Mortality: A Decision-Tree Analysis.Clinics and practice · 2026Article
- Early Prediction of Delirium in Postcardiac Surgery Patients: Machine Learning Model Development and External Validation.JMIR medical informatics · 2026Article
- Association between acute kidney injury, delirium and outcomes in patients with critical illness: a protocol for a systematic review.BMJ open · 2025Article
- Impact of postoperative delirium on long-term neurologic and neuropsychiatric outcome after cardiac surgery or percutaneous valve replacement-a prospective observational study.Frontiers in cardiovascular medicine · 2025Article
- Neurofilament light chains to assess sepsis-associated encephalopathy: Are we on the track toward clinical implementation?Critical care (London, England) · 2023Review
- Elderly Patients and Management in Intensive Care Units (ICU): Clinical Challenges.Clinical interventions in aging · 2023Review
- Review
- Psychiatric Disorder Incidence Among Adolescents and Young Adults Aged 15-39 With Cancer: Population-Based Cohort.JNCI cancer spectrum · 2022Article
- Clinical Subtypes of Sepsis Survivors Predict Readmission and Mortality after Hospital Discharge.Annals of the American Thoracic Society · 2022Observational
- Risk factors, time to onset and recurrence of delirium in a mixed medical-surgical ICU population: A secondary analysis using Cox and CHAID decision tree modeling.EXCLI journal · 2022Article
- [Focus on neurological intensive care medicine. Intensive care studies from 2020/2021].Der Anaesthesist · 2021Article
- What's New in Critical Illness and Injury Science? Evidence and limitations for using S100β to diagnose and risk stratify critically ill patients with delirium.International journal of critical illness and injury scienceArticle
- What's New in Critical Illness and Injury Science? Delirium, COVID-19, and critical illness.International journal of critical illness and injury scienceArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients in the intensive care unit (ICU) are known to be at increased risk of developing delirium, but the risk of subsequent neuropsychiatric disorders is unclear. We therefore sought to examine the association between the presence of delirium in the ICU and incident neuropsychiatric disorders (including depressive, anxiety, trauma-and-stressor-related, and neurocognitive disorders) post-ICU stay among adult medical-surgical ICU patients.
methodsRetrospective cohort study utilizing clinical and administrative data from both inpatient and outpatient healthcare visits to identify the ICU cohort and diagnostic information 5 years prior to and 1 year post-ICU stay. Patients ≥ 18 years of age admitted to one of 14 medical-surgical ICUs across Alberta, Canada, January 1, 2014-June 30, 2016, and survived to hospital discharge were included. The main outcome of interest was a new diagnosis of any neuropsychiatric disorder 1 year post-ICU stay. The exposure variable was delirium during the ICU stay identified through any positive delirium screen by the Intensive Care Unit Delirium Screening Checklist (ICDSC) during the ICU stay.
resultsOf 16,005 unique patients with at least one ICU admission, 4033 patients were included in the study of which 1792 (44%) experienced delirium during their ICU stay. The overall cumulative incidence of any neuropsychiatric disorder during the subsequent year was 19.7% for ICU patients. After adjusting for hospital characteristics using log-binomial regression, patients with delirium during the ICU stay had a risk ratio (RR) of 1.14 (95% confidence interval [CI] 0.98-1.33) of developing any neuropsychiatric disorder within 1 year post-ICU compared to those who did not experience delirium. Delirium was significantly associated with neurocognitive disorders (RR 1.59, 95% CI 1.08-2.35), but not depressive disorders (RR 1.16, 95% CI 0.92-1.45), anxiety (RR 1.16, 95% CI 0.92-1.47), and trauma-and-stressor-related (RR 0.82, 95% CI 0.53-1.28) disorders.
conclusionsThe diagnosis of new onset of neurocognitive disorders is associated with ICU-acquired delirium. In this study, significant associations were not observed for depressive, anxiety, and trauma-and-stressor-related disorders.
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