Evidence map›Paper›PMID 32736539›Full record

ArticleBMC cancer2020

Methylation of WT1, CA10 in peripheral blood leukocyte is associated with breast cancer risk: a case-control study.

Anqi Ge, Song Gao, Yupeng Liu, Hui Zhang, Xuan Wang, Lei Zhang, Da Pang, Yashuang Zhao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Anqi GeDepartment of Epidemiology, School of Public Health, Harbin Medical University, 57 Baojian Street, Nangang District, Harbin, 150081, Heilongjiang Province, People's Republic of China.
Song GaoDepartment of Breast Surgery, the Tumor Hospital of Harbin Medical University, 150 Haping Street, Nangang District, Harbin, 150081, Heilongjiang Province, People's Republic of China.
Yupeng LiuDepartment of Epidemiology, School of Public Health, Harbin Medical University, 57 Baojian Street, Nangang District, Harbin, 150081, Heilongjiang Province, People's Republic of China.
Hui ZhangDepartment of Epidemiology, School of Public Health, Harbin Medical University, 57 Baojian Street, Nangang District, Harbin, 150081, Heilongjiang Province, People's Republic of China.
Xuan WangDepartment of Epidemiology, School of Public Health, Harbin Medical University, 57 Baojian Street, Nangang District, Harbin, 150081, Heilongjiang Province, People's Republic of China.
Lei ZhangDepartment of Epidemiology, School of Public Health, Harbin Medical University, 57 Baojian Street, Nangang District, Harbin, 150081, Heilongjiang Province, People's Republic of China.
Da PangDepartment of Breast Surgery, the Tumor Hospital of Harbin Medical University, 150 Haping Street, Nangang District, Harbin, 150081, Heilongjiang Province, People's Republic of China. pangda@ems.hrbmu.edu.cn.
Yashuang ZhaoDepartment of Epidemiology, School of Public Health, Harbin Medical University, 57 Baojian Street, Nangang District, Harbin, 150081, Heilongjiang Province, People's Republic of China. zhao_yashuang@263.net.ORCID http://orcid.org/0000-0002-7425-5773
Harbin Medical University · CN

Funding

National Natural Science Foundation of China 81172743
6 · The paper itself

Abstract

backgroundStudies have shown that abnormal changes of specific-gene DNA methylation in leukocytes may be associated with an elevated risk of cancer. However, associations between the methylation of the zinc-related genes, WT1 and CA10, and breast cancer risk remain unknown.

methodsThe methylation of WT1 and CA10 was analyzed by methylation-sensitive high-resolution-melting (MS-HRM) in a case-control study with female subjects (N = 959). Logistic regression was used to analyze the associations, and propensity score (PS) method was used to adjust confounders.

resultsThe results showed that WT1 hypermethylation was associated with an increased risk of breast cancer, with an odds ratio (OR) of 3.07 [95% confidence interval (CI): 1.67-5.64, P < 0.01]. Subgroup analyses showed that WT1 hypermethylation was specifically associated with an elevated risk of luminal A subtype (OR = 2.62, 95% CI: 1.11-6.20, P = 0.03) and luminal B subtype (OR = 3.23, 95% CI: 1.34-7.80, P = 0.01). CA10 hypermethylation was associated with an increased risk of luminal B subtype (OR = 1.80, 95% CI: 1.09-2.98, P = 0.02).

conclusionThe results of the present study suggest that the hypermethylation of WT1 methylation in leukocytes is significantly associated with an increased risk of breast cancer. The hypermethylation of WT1 is associated with an increased risk of luminal subtypes of breast cancer, and the hypermethylation of CA10 is associated with an increased risk of luminal B subtype of breast cancer.

Indexed as

DNA MethylationGenes, Wilms TumorAdultAgedBreast NeoplasmsCarcinoma, Intraductal, NoninfiltratingCase-Control StudiesFemaleHumansLeukocytesMiddle AgedNerve Tissue ProteinsCA10 protein, humanNerve Tissue ProteinsBreast cancerCA10DNA methylationLeukocytesWT1

Identifiers

PMID32736539
PMCPMC7393705
OpenAlexW3046319347

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.