ArticleJournal of neural engineering2020
The relationship between morphological properties and thresholds to extracellular electric stimulation in α RGCs.
Article in Journal of neural engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Voltage-gated sodium channels in the nervous system: Molecular physiology to therapeutic interventions.Neural regeneration research · 2026Article
- Population-scale analysis of frequency-dependent calcium dynamics in retinal ganglion cells under electric field stimulation.Scientific reports · 2026Article
- Computational modelling of the suppression of optic nerve fibre.Medical & biological engineering & computing · 2026Article
- Population-Scale Analysis of Frequency-Dependent Calcium Dynamics in Retinal Ganglion Cells Under Electric Field Stimulation.bioRxiv : the preprint server for biology · 2026Article
- Article
- Differential Intrinsic Firing Properties in Sustained and Transient Mouse αRGCs Match Their Light Response Characteristics and Persist during Retinal Degeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Transparent and Conformal Microcoil Arrays for Spatially Selective Neuronal Activation.Device · 2024Article
- Dendrites contribute to the gradient of intrinsic timescales encompassing cortical and subcortical brain networks.Frontiers in cellular neuroscience · 2024Article
- Patient-specific computational models of retinal prostheses.Scientific reports · 2023Article
- Topology recapitulates morphogenesis of neuronal dendrites.Cell reports · 2023Article
- Inference of Electrical Stimulation Sensitivity from Recorded Activity of Primate Retinal Ganglion Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Modeling extracellular stimulation of retinal ganglion cells: theoretical and practical aspects.Journal of neural engineering · 2023Article
- Implications of Neural Plasticity in Retinal Prosthesis.Investigative ophthalmology & visual science · 2022Article
- Article
- Morphological Factors that Underlie Neural Sensitivity to Stimulation in the Retina.Advanced nanobiomed research · 2021Article
- The effect of axon trajectory on retinal ganglion cell activation with epiretinal stimulation.International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering · 2021Article
- The impact of synchronous versus asynchronous electrical stimulation in artificial vision.Journal of neural engineering · 2021Review
- Layer-specific parameters of intracortical microstimulation of the somatosensory cortex.Journal of neural engineering · 2021Article
- Block Phenomena During Electric Micro-Stimulation of Pyramidal Cells and Retinal Ganglion Cells.Frontiers in cellular neuroscience · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveRetinal prostheses strive to restore vison to patients that are blind from retinal degeneration by electrically stimulating surviving retinal ganglion cells (RGCs). The quality of elicited percepts remains limited however and it is desirable to develop improved stimulation strategies. Here, we examine how the anatomical and biophysical properties of RGCs influence activation thresholds, including the effects of variations found naturally. APPROACH: Detailed reconstructions were made of a large number of mouse α RGCs and were used to create an array of model cells; the models were used to study the effects of individual anatomical features on activation threshold to electric stimulation. Stimulation was delivered epiretinally from a point-source or disk electrode and consisted of monophasic or biphasic rectangular pulses. MAIN
resultsModeling results show that the region of minimum threshold always is within the axon initial segment (AIS). The properties of this region as well as the absolute value of the minimum threshold are dependent on the length of the AIS as well as on the relative composition of sodium channels within the AIS. Other morphological features, including cell size, dendritic field size and the distance between the AIS and the soma had only a minimal influence on thresholds. Introducing even a small number of low-threshold Na SIGNIFICANCE: Intrinsic morphological features can influence activation thresholds with the AIS having the strongest influence. However, the combined influence remains limited and may not be large enough to allow for selective activation between different RGC types.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.