ArticleEBioMedicine2020
Associations of rest-activity patterns with amyloid burden, medial temporal lobe atrophy, and cognitive impairment.
Article in EBioMedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- AI and Wearables for Early Detection of Cognitive Impairment and Dementia: Systematic Review.Journal of medical Internet research · 2026Pooled it
- Influence of age, cognitive function, attention, and mental state on the effectiveness of EEG-based brain-computer interface device use: a systematic review.Journal of neuroengineering and rehabilitation · 2025Pooled it
- Functional MRI-Specific Alterations in Executive Control Network in Mild Cognitive Impairment: An ALE Meta-Analysis.Frontiers in aging neuroscience · 2020Pooled it
- Platelet proteomic signatures of amyloid β-positive mild cognitive impairment and Alzheimer's disease.Molecular brain · 2026Article
- Cellular circadian period and its deviation associate with Alzheimer's pathology and brain aging in cognitively impaired older adults.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Longitudinal associations of rest-activity rhythms with executive function, plasma biomarkers, and clinical outcomes in older adults.Frontiers in aging neuroscience · 2026Article
- Article
- Associations between accelerometer-measured circadian rest-activity rhythm, brain structural and genetic mechanisms, and dementia.Psychiatry and clinical neurosciences · 2024Article
- Upsetting the Balance: How Modifiable Risk Factors Contribute to the Progression of Alzheimer's Disease.Biomolecules · 2024Review
- Comparing the Efficacy of Two Cognitive Screening Tools in Identifying Gray and White Matter Brain Damage among Older Adults.Journal of aging research · 2024Article
- Circadian rest-activity rhythm and longitudinal brain changes underlying late-life cognitive decline.Psychiatry and clinical neurosciences · 2023Article
- Exploring Shared Effects of Multisensory Impairment, Physical Dysfunction, and Cognitive Impairment on Physical Activity: An Observational Study in a National Sample.Journal of aging and physical activity · 2022Observational
- Associations of actigraphy derived rest activity patterns and circadian phase with clinical symptoms and polysomnographic parameters in chronic insomnia disorders.Scientific reports · 2022Article
- Baseline Clinical and Biomarker Characteristics of Biobank Innovations for Chronic Cerebrovascular Disease With Alzheimer's Disease Study: BICWALZS.Psychiatry investigation · 2022Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe sought to investigate the possible associations of rest-activity patterns with cortical amyloid burden, medial temporal lobe (MTL) neurodegeneration, and cognitive function in patients in the early stage of cognitive impairment.
methodsRest-activity patterns were assessed in 100 participants (70 with mild cognitive impairment and 30 with mild dementia) using wrist actigraphy. All participants underwent
findingsAfter adjusting for possible confounders, we found that the midline estimation of statistic of rhythm (MESOR) associated positively with frontal/executive function (estimate = 1.17, standard error [SE] = 0.37, p = 0.002). The least active 5-h (L5) onset time associated positively with MTL grey matter volume and memory function (estimate = 1.24, SE = 0.33, p = 0.001, and estimate = 3.77, SE = 1.22, p = 0.003, respectively), particularly in amyloid-negative participants. Additional path analysis revealed that MTL grey matter volume partially mediated the association between L5 onset time and memory function in amyloid-negative participants.
interpretationDecreased MESOR and advanced L5 onset time may be useful as early signs of cognitive decline or MTL neurodegeneration. Furthermore, amyloid pathology may act as a moderator of the relationships between rest-activity patterns, neurodegeneration, and cognitive function.
fundingKorea Centres for Disease Control and Prevention (#4845-303); National Research Foundation of Korea (2019M3C7A1031905, 2019R1A5A2026045).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.