Evidence map›Paper›PMID 32736169›Full record

ArticleBiomaterials2020

Photocontrolled miR-148b nanoparticles cause apoptosis, inflammation and regression of Ras induced epidermal squamous cell carcinomas in mice.

Yiming Liu, Jacob T Bailey, Mohammad Abu-Laban, Shue Li, Cong Chen, Adam B Glick, Daniel J Hayes

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yiming LiuDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, United States.
Jacob T BaileyDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, 16802, United States.
Mohammad Abu-LabanDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, United States.
Shue LiDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, United States.
Cong ChenDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, United States.
Adam B GlickDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, 16802, United States; The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA, 16802, United States; The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, 16802, United States. Electronic address: abg11@psu.edu.
Daniel J HayesDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, United States; Material Research Institute, The Pennsylvania State University, University Park, PA, 16802, United States; The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, 16802, United States. Electronic address: djh195@psu.edu.
Pennsylvania State University · US

Funding

Spatiotemporal Modulation of Osteogenesis in a 3-D Stromal/Stem Cell ModelR01DE024790 · NIDCR · PENNSYLVANIA STATE UNIVERSITY, THE · PI HAYES, DANIEL J. · 2015 to 2019
$1.7M
NIDCR NIH HHS R01 DE024790
6 · The paper itself

Abstract

Despite evidence that microRNAs (miRNAs) are essential in modulating tumorigenesis, a major challenge in cancer treatment is to achieve tumor-specific selectivity and efficient yet safe delivery of miRNAs in vivo. In this study, we have developed a light-inducible silver nanoparticle nucleic acid delivery system that demonstrates precise spatiotemporal control, high cellular uptake, low cytotoxicity, escape from endosomes and release of functional miRNA into the cytosol. Using this approach, we delivered exogenous miR-148b to induce apoptosis in Ras-expressing keratinocytes and murine squamous cell carcinoma cells while avoiding cytotoxicity in untransformed keratinocytes. When administered to transgenic mice with HRas

Indexed as

Carcinoma, Squamous CellMetal NanoparticlesMicroRNAsNanoparticlesAnimalsApoptosisInflammationMiceSilverMicroRNAsSilverImmunomodulationmicroRNAsRasretro-Diels-AlderSilver nanoparticles

Identifiers

PMID32736169
PMCPMC7570449
OpenAlexW3036731085

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.