Evidence map›Paper›PMID 32735934›Full record

ArticleBrain, behavior, and immunity2020

Genetic liability to major depression and risk of childhood asthma.

Xiaoqin Liu, Trine Munk-Olsen, Clara Albiñana, Bjarni J Vilhjálmsson, Emil M Pedersen, Vivi Schlünssen, Marie Bækvad-Hansen, Jonas Bybjerg-Grauholm, Merete Nordentoft, Anders D Børglum and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  5. Paediatric asthma and non-allergic comorbidities: A review of current risk and proposed mechanisms.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Xiaoqin LiuNCRR-The National Centre for Register-based Research, Aarhus University, Aarhus, Denmark; iPSYCH-Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark. Electronic address: lxq@econ.au.dk.
Trine Munk-OlsenNCRR-The National Centre for Register-based Research, Aarhus University, Aarhus, Denmark; iPSYCH-Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark.
Clara AlbiñanaNCRR-The National Centre for Register-based Research, Aarhus University, Aarhus, Denmark; iPSYCH-Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark.
Bjarni J VilhjálmssonNCRR-The National Centre for Register-based Research, Aarhus University, Aarhus, Denmark; iPSYCH-Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark; CIRRAU-Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark.
Emil M PedersenNCRR-The National Centre for Register-based Research, Aarhus University, Aarhus, Denmark; iPSYCH-Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark.
Vivi SchlünssenNational Research Center for the Working Environment, Copenhagen, Denmark; Department of Public Health, Environment, Work and Health, Danish Ramazzini Centre, Aarhus University, Denmark.
Marie Bækvad-HanseniPSYCH-Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark; Danish Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
Jonas Bybjerg-GrauholmiPSYCH-Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark; Danish Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
Merete NordentoftiPSYCH-Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark; Mental Health Centre Copenhagen, Copenhagen, Denmark; Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Anders D BørglumiPSYCH-Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark; Department of Biomedicine, Aarhus University, Aarhus, Denmark; iSEQ, Center for Integrative Sequencing, and Center for Genomics and Personalized Medicine, Aarhus, Denmark.
Thomas WergeiPSYCH-Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark; Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Capital Region of Denmark, Copenhagen, Denmark.
David M HougaardiPSYCH-Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark; Danish Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
Preben B MortensenNCRR-The National Centre for Register-based Research, Aarhus University, Aarhus, Denmark; iPSYCH-Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark; CIRRAU-Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark; iSEQ, Center for Integrative Sequencing, and Center for Genomics and Personalized Medicine, Aarhus, Denmark.
Esben AgerboNCRR-The National Centre for Register-based Research, Aarhus University, Aarhus, Denmark; iPSYCH-Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark; CIRRAU-Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark.
Lundbeck Foundation · DKAarhus University · DKCapital Region of Denmark · DKNational Research Centre for the Working Environment · DKStatens Serum Institut · DK

Funding

Relapse risk after Discontinuation of Antidepressants during Pregnancy (R-DAP study)R01MH122869 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Veerle Bergink · 2020 to 2026
$4.3M
NIMH NIH HHS R01 MH122869
6 · The paper itself

Abstract

objectiveMajor depression and asthma frequently co-occur, suggesting shared genetic vulnerability between these two disorders. We aimed to determine whether a higher genetic liability to major depression was associated with increased childhood asthma risk, and if so, whether such an association differed by sex of the child.

methodsWe conducted a population-based cohort study comprising 16,687 singletons born between 1991 and 2005 in Denmark. We calculated the polygenic risk score (PRS) for major depression as a measure of genetic liability based on the summary statistics from the Major Depressive Disorder Psychiatric Genomics Consortium collaboration. The outcome was incident asthma from age 5 to 15 years, identified from the Danish National Patient Registry and the Danish National Prescription Registry. Stratified Cox regression was used to analyze the data.

resultsGreater genetic liability to major depression was associated with an increased asthma risk with a hazard ratio (HR) of 1.06 (95% CI: 1.01-1.10) per standard deviation increase in PRS. Children in the highest major depression PRS quartile had a HR for asthma of 1.20 (95% CI: 1.06-1.36), compared with children in the lowest quartile. However, major depression PRS explained only 0.03% of asthma variance (Pseudo-R

conclusionOur results suggest a shared genetic contribution to major depression and childhood asthma, and there is no evidence of a sex-specific difference in the association.

Indexed as

AsthmaMajor Depressive DisorderAdolescentChildChild, PreschoolCohort StudiesDepressionFemaleHumansMaleMultifactorial InheritanceAsthmaCohort studyGenetic liabilityMajor depressionPolygenic risk scorePopulation-based

Identifiers

PMID32735934
PMCPMC8817239
OpenAlexW3045698495

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.