Evidence map›Paper›PMID 32735893›Full record

ArticleThe Journal of infection2020

Increased risk of SARS-CoV-2 infection in staff working across different care homes: enhanced CoVID-19 outbreak investigations in London care Homes.

Shamez N Ladhani, J Yimmy Chow, Roshni Janarthanan, Jonathan Fok, Emma Crawley-Boevey, Amoolya Vusirikala, Elena Fernandez, Marina Sanchez Perez, Suzanne Tang, Kate Dun-Campbell and 21 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of infection, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 2 pooled it
25.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 111 citations in OpenAlex.

  1. Effectiveness of social distancing measures and lockdowns for reducing transmission of COVID-19 in non-healthcare, community-based settings.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2023
    Pooled it
  2. COVID-19 Prevention and Control Measures in Workplace Settings: A Rapid Review and Meta-Analysis.International journal of environmental research and public health · 2021
    Pooled it
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

31 authors at 2 institutions in 1 country.

Shamez N LadhaniImmunisation and Countermeasures Division, Public Health England, 61 Colindale Avenue, London NW9 5EQ, UK; Paediatric Infectious Diseases Research Group, St. George's University of London, UK. Electronic address: shamez.ladhani@phe.gov.uk.
J Yimmy ChowLondon Health Protection team, National Infection Service, Public Health England, London, UK.
Roshni JanarthananLondon Health Protection team, National Infection Service, Public Health England, London, UK.
Jonathan FokLondon Health Protection team, National Infection Service, Public Health England, London, UK.
Emma Crawley-BoeveyLondon Health Protection team, National Infection Service, Public Health England, London, UK.
Amoolya VusirikalaLondon Health Protection team, National Infection Service, Public Health England, London, UK.
Elena FernandezLondon Health Protection team, National Infection Service, Public Health England, London, UK.
Marina Sanchez PerezLondon Health Protection team, National Infection Service, Public Health England, London, UK.
Suzanne TangLondon Health Protection team, National Infection Service, Public Health England, London, UK.
Kate Dun-CampbellLondon Health Protection team, National Infection Service, Public Health England, London, UK.
Edward Wynne-EvansLondon Health Protection team, National Infection Service, Public Health England, London, UK.
Anita BellLondon Health Protection team, National Infection Service, Public Health England, London, UK.
Bharat PatelLondon Health Protection team, National Infection Service, Public Health England, London, UK.
Zahin Amin-ChowdhuryImmunisation and Countermeasures Division, Public Health England, 61 Colindale Avenue, London NW9 5EQ, UK.
Felicity AianoImmunisation and Countermeasures Division, Public Health England, 61 Colindale Avenue, London NW9 5EQ, UK.
Karthik ParanthamanField Service, National Infection Service, Public Health England.
Thomas MaField Service, National Infection Service, Public Health England.
Maria Saavedra-CamposField Service, National Infection Service, Public Health England.
Richard MyersInfectious Disease Informatics, Public Health England, London, UK.
Joanna EllisVirus Reference department, Public Health England, London, UK.
Angie LackenbyVirus Reference department, Public Health England, London, UK.
Robin GopalVirus Reference department, Public Health England, London, UK.
Monika PatelVirus Reference department, Public Health England, London, UK.
Meera ChandAntimicrobial Resistance and Hospital Acquired Infection Department, Public Health England, London, UK.
Kevin BrownVirus Reference department, Public Health England, London, UK.
Susan HopkinsAntimicrobial Resistance and Hospital Acquired Infection Department, Public Health England, London, UK.
CoG ConsortiumCOVID-19 Genomics UK Consortium (https://www.cogconsortium.uk/).
Nandini ShettyVirus Reference department, Public Health England, London, UK.
Maria ZambonVirus Reference department, Public Health England, London, UK.
Mary E RamsayImmunisation and Countermeasures Division, Public Health England, 61 Colindale Avenue, London NW9 5EQ, UK.
London Care Home Investigation Team
Public Health England · GBSt George's, University of London · GB

Funding

Medical Research Council MC_PC_19027
6 · The paper itself

Abstract

backgroundCare homes have been disproportionately affected by the COVID-19 pandemic and continue to suffer large outbreaks even when community infection rates are declining, thus representing important pockets of transmission. We assessed occupational risk factors for SARS-CoV-2 infection among staff in six care homes experiencing a COVID-19 outbreak during the peak of the pandemic in London, England.

methodsCare home staff were tested for SARS-COV-2 infection by RT-PCR and asked to report any symptoms, their contact with residents and if they worked in different care homes. Whole genome sequencing (WGS) was performed on RT-PCR positive samples.

resultsIn total, 53 (21%) of 254 staff were SARS-CoV-2 positive but only 12/53 (23%) were symptomatic. Among staff working in a single care home, SARS-CoV-2 positivity was 15% (2/13), 16% (7/45) and 18% (30/169) in those reporting no, occasional and regular contact with residents. In contrast, staff working across different care homes (14/27, 52%) had a 3.0-fold (95% CI, 1.9-4.8; P<0.001) higher risk of SARS-CoV-2 positivity than staff working in single care homes (39/227, 17%). WGS identified SARS-CoV-2 clusters involving staff only, including some that included staff working across different care homes.

conclusionsSARS-CoV-2 positivity was significantly higher among staff working across different care homes than those who were working in the same care home. We found local clusters of SARS-CoV-2 infection between staff only, including those with minimal resident contact. Infection control should be extended for all contact, including those between staff, whilst on care home premises.

Indexed as

BetacoronavirusCoronavirus InfectionsCOVID-19EnglandGenome, ViralHomes for the AgedHumansInfection ControlLondonMedical StaffNursing HomesOccupational ExposurePandemicsPneumonia, ViralSARS-CoV-2Whole Genome SequencingCare homesCOVID-19Occupational riskSARS-CoV-2Transmission

Identifiers

PMID32735893
PMCPMC7387283
OpenAlexW3045888259

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.