Evidence map›Paper›PMID 32735863›Full record

ArticleArchives of biochemistry and biophysics2020

Nanodisc scaffold peptide (NSP

Bryan Neumann, Kevin Chao, Catherine C Y Chang, Ta-Yuan Chang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of biochemistry and biophysics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Bryan NeumannDepartment of Biochemistry & Cell Biology, Geisel School of Medicine, Dartmouth College, Hanover, NH, 03755, USA.
Kevin ChaoCollege of Medicine, SUNY Downstate Health Sciences University, Brooklyn, NY, 11203, USA.
Catherine C Y ChangDepartment of Biochemistry & Cell Biology, Geisel School of Medicine, Dartmouth College, Hanover, NH, 03755, USA. Electronic address: Catherine.C.Chang@Dartmouth.edu.
Ta-Yuan ChangDepartment of Biochemistry & Cell Biology, Geisel School of Medicine, Dartmouth College, Hanover, NH, 03755, USA. Electronic address: Ta.Yuan.Chang@Dartmouth.edu.

Funding

Understanding the role of RNA-binding protein mutations in cancerP20GM113132 · NIGMS · DARTMOUTH COLLEGE · PI MADDEN, DEAN R · 2016 to 2025
$25.9M
Impact of microglial cholesterol storage on neuroinflammationR01AG037609 · NIA · DARTMOUTH COLLEGE · PI CHANG, TA YUAN · 2010 to 2019
$3.3M
Alleviating lysosomal lipid defects in ADRD by blocking cholesterol storageR01AG063544 · NIA · DARTMOUTH COLLEGE · PI CHANG, TA YUAN · 2018 to 2021
$2.3M
NIA NIH HHS R01 AG037609NIA NIH HHS R01 AG063544NIGMS NIH HHS P20 GM113132
6 · The paper itself

Abstract

To conduct biochemical studies in vitro, membrane proteins (MPs) must be solubilized with detergents. While detergents are great tools, they can also inhibit the biological activity and/or perturb oligomerization of individual MPs. Nanodisc scaffold peptide (NSP

Indexed as

Amino Acid SequenceAnimalsCHO CellsCholic AcidsCricetulusDetergentsDigitoninHumansPeptidesProtein DomainsProtein MultimerizationSterol O-AcyltransferaseSurface-Active Agents3-((3-cholamidopropyl)dimethylammonium)-1-propanesulfonateCholic AcidsDetergentsDigitoninPeptidesSterol O-Acyltransferasesterol O-acyltransferase 1Surface-Active AgentsACAT/SOATDetergent-freeMembrane proteinOligomerizationPeptidiscPhospholipid

Identifiers

PMID32735863
PMCPMC7507747

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.