ArticleStem cell reports2020
A Single Radioprotective Dose of Prostaglandin E
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In one paragraph
Article in Stem cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Advances in the Regulation of Hematopoietic Homeostasis by Programmed Cell Death Under Radiation Conditions.Stem cell reviews and reports · 2025Pooled it
- Breaking through the radiation dilemma: development and clinical translation of anti-radiation drugs.Pharmaceutical science advances · 2026Review
- Mesenchymal stromal cells modulate survival and regeneration of human hematopoietic stem cells via PGE2/cAMP signaling.Cell death & disease · 2026Article
- Single-cell transcriptomics reveals BMP4-BMPR2 signaling promotes radiation resistance in hematopoietic stem cells following injury.Nature communications · 2025Article
- Role of Neurotransmitters in Steady State Hematopoiesis, Aging, and Leukemia.Stem cell reviews and reports · 2025Review
- Insights into ionizing radiation-induced bone marrow hematopoietic stem cell injury.Stem cell research & therapy · 2024Review
- tRNA mNature communications · 2024Article
- Indole-3-carboxaldehyde ameliorates ionizing radiation-induced hematopoietic injury by enhancing hematopoietic stem and progenitor cell quiescence.Molecular and cellular biochemistry · 2024Article
- Pharmacokinetics and Biodistribution of 16,16 dimethyl Prostaglandin E2 in Non-Irradiated and Irradiated Mice and Non-Irradiated Non-Human Primates.Radiation research · 2024Article
- Exploring the Potential of Metformin in Mitigating Radiation-induced Gastrointestinal and Hematopoietic System Injury in Rats After Whole-body X-ray Radiation: An Experimental Study.Current radiopharmaceuticals · 2024Article
- The gut microbiota as a booster for radiotherapy: novel insights into radio-protection and radiation injury.Experimental hematology & oncology · 2023Review
- Further Characterization of Multi-Organ DEARE and Protection by 16,16 Dimethyl Prostaglandin E2 in a Mouse Model of the Hematopoietic Acute Radiation Syndrome.Radiation research · 2023Article
- The delayed effects of acute radiation exposure (DEARE): characteristics, mechanisms, animal models, and promising medical countermeasures.International journal of radiation biology · 2023Review
- Upregulation of SIRT1 Contributes to dmPGE2-dependent Radioprotection of Hematopoietic Stem Cells.Stem cell reviews and reports · 2022Article
- Leukemia Inhibitory Factor Promotes Survival of Hematopoietic Progenitors Ex Vivo and Is Post-Translationally Regulated by DPP4.Stem cells (Dayton, Ohio) · 2022Article
- Mitigation of Ionizing Radiation-Induced Gastrointestinal Damage by Insulin-Like Growth Factor-1 in Mice.Frontiers in pharmacology · 2022Article
- External signals regulate continuous transcriptional states in hematopoietic stem cells.eLife · 2021Article
- Meloxicam with Filgrastim may Reduce Oxidative Stress in Hematopoietic Progenitor Cells during Mobilization of Autologous Peripheral Blood Stem Cells in Patients with Multiple Myeloma.Stem cell reviews and reports · 2021Article
- Prostaglandin EStem cell reviews and reports · 2021Article
- Prostaglandin EStem cell reviews and reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Andrea M PattersonDepartment of Microbiology & Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.
Liqiong LiuDepartment of Microbiology & Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.
Carol H SampsonDepartment of Medicine/Hematology Oncology, Indiana University School of Medicine, Indianapolis, IN, USA.
P Artur PlettDepartment of Medicine/Hematology Oncology, Indiana University School of Medicine, Indianapolis, IN, USA.
Hongge LiDepartment of Microbiology & Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.
Pratibha SinghDepartment of Microbiology & Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.
Khalid S MohammadDepartment of Medicine/Endocrinology, Indiana University School of Medicine, Indianapolis, IN, USA.
Jonathan HoggattCenter for Cancer Research and Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA, USA.
Maegan L CapitanoDepartment of Microbiology & Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.
Christie M OrschellDepartment of Medicine/Hematology Oncology, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: corschel@iupui.edu.
Louis M PelusDepartment of Microbiology & Immunology, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Medicine/Hematology Oncology, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: lpelus@iupui.edu.
Funding
Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Jun Wan · 1999 to 2026
$59.3MBASIC SCIENCE STUDIES ON GENE THERAPY OF BLOOD DISEASEST32HL007910 · NHLBI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Roland W. Herzog, Reuben Kapur · 1999 to 2026
$7.6MRegulating hematopoietic stem cells and hematopoiesis for clinical efficacyP30DK090948 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI BROXMEYER, HAL E., SROUR, EDWARD F · 2010 to 2014
$3.7MRole of PGE2 and other eicosanoids in hematopoietic stem cell functionR01HL096305 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI PELUS, LOUIS M · 2010 to 2018
$3.5MNCI NIH HHS P30 CA082709NHLBI NIH HHS R01 HL096305NHLBI NIH HHS T32 HL007910NIDDK NIH HHS P30 DK090948
Abstract
Ionizing radiation exposure results in acute and delayed bone marrow suppression. Treatment of mice with 16,16-dimethyl prostaglandin E
Indexed as
Radiation, IonizingAnimalsApoptosisCell CycleDinoprostoneDNA DamageGene Expression RegulationGene Regulatory NetworksHematopoiesisHematopoietic Stem CellsMice, Inbred C57BLRadiation-Protective AgentsSignal TransductionTranscription FactorsTranscription, GeneticDinoprostoneRadiation-Protective AgentsTranscription Factors16,16-dimethyl PGE(2)bone marrowcell cycleDNA damagehematopoietic regenerationp53prostaglandinradiationRNA sequencingstem cells
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.