Evidence map›Paper›PMID 32735820›Full record

ArticleStem cell reports2020

The Periostin/Integrin-αv Axis Regulates the Size of Hematopoietic Stem Cell Pool in the Fetal Liver.

Atreyi Biswas, Irene M Roy, Prathibha C Babu, Javed Manesia, Sarah Schouteden, Vinod Vijayakurup, Ruby John Anto, Joerg Huelsken, Adam Lacy-Hulbert, Catherine M Verfaillie and 1 more

Open access · goldAbstract read
In one paragraph

Article in Stem cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

  1. Scleral Postn Drives Myopia via Promoting Myofibroblast Transdifferentiation.Investigative ophthalmology & visual science · 2026
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  5. The Clonal Hematopoiesis-associated GenebioRxiv : the preprint server for biology · 2024
    Article
  6. Article
  7. Article
  8. The evolving hematopoietic niche during development.Frontiers in molecular biosciences · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Clonal Hematopoiesis: Role in Hematologic and Non-Hematologic Malignancies.Mediterranean journal of hematology and infectious diseases · 2022
    Review
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 4 countries.

Atreyi BiswasSchool of Biology, Indian Institute of Science Education and Research Thiruvananthapuram, Thiruvananthapuram, Kerala 695551, India.
Irene M RoySchool of Biology, Indian Institute of Science Education and Research Thiruvananthapuram, Thiruvananthapuram, Kerala 695551, India.
Prathibha C BabuSchool of Biology, Indian Institute of Science Education and Research Thiruvananthapuram, Thiruvananthapuram, Kerala 695551, India.
Javed ManesiaInter-Departmental Stem Cell Institute, KU Leuven, 3000 Leuven, Belgium.
Sarah SchoutedenInter-Departmental Stem Cell Institute, KU Leuven, 3000 Leuven, Belgium.
Vinod VijayakurupRajiv Gandhi Centre for Biotechnology, Poojappura, Thiruvananthapuram, Kerala, India.
Ruby John AntoRajiv Gandhi Centre for Biotechnology, Poojappura, Thiruvananthapuram, Kerala, India.
Joerg HuelskenÉcole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Adam Lacy-HulbertBenaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA.
Catherine M VerfaillieInter-Departmental Stem Cell Institute, KU Leuven, 3000 Leuven, Belgium.
Satish KhuranaSchool of Biology, Indian Institute of Science Education and Research Thiruvananthapuram, Thiruvananthapuram, Kerala 695551, India. Electronic address: satishkhurana@iisertvm.ac.in.
Indian Institute of Science Education and Research Thiruvananthapuram · INKU Leuven · BERajiv Gandhi Centre for Biotechnology · INÉcole Polytechnique Fédérale de Lausanne · CHVirginia Mason Medical Center · US

Funding

DBT-Wellcome Trust India Alliance IA/I/15/2/502061Wellcome Trust
6 · The paper itself

Abstract

We earlier showed that outside-in integrin signaling through POSTN-ITGAV interaction plays an important role in regulating adult hematopoietic stem cell (HSC) quiescence. Here, we show that Itgav deletion results in increased frequency of phenotypic HSCs in fetal liver (FL) due to faster proliferation. Systemic deletion of Postn led to increased proliferation of FL HSCs, albeit without any loss of stemness, unlike Vav-Itgav

Indexed as

Signal TransductionAnimalsCell Adhesion MoleculesDNA DamageDNA RepairEndothelium, VascularFetusGene DeletionHematopoietic Stem CellsIntegrin alphaVIntegrin beta3LiverMiceMice, KnockoutPhenotypeCell Adhesion MoleculesIntegrin alphaVIntegrin beta3Postn protein, mouseDNA damage responsesfetal liverfetal liver nichehematopoietic stem cellsoutside-in integrin signalingPOSTN-ITGAV interaction

Identifiers

PMID32735820
PMCPMC7419718
OpenAlexW3045593465

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.