ArticleCurrent biology : CB2020
Causal Contribution of Awake Post-encoding Processes to Episodic Memory Consolidation.
Article in Current biology : CB, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06276400 (Lateral Prefrontal Organization in Emotion), which is not on this map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Lateral Prefrontal Organization in Emotion: Representational and Causal Mechanism - Duration Difference Estimation
Who cites it
30 citing papers in PubMed, 56 citations in OpenAlex.
- Post-encoding administration of oxytocin selectively enhances memory consolidation of male faces in females.Proceedings of the National Academy of Sciences of the United States of America · 2026Trial
- Condition-specific neural signatures of reactivation during post-retrieval rest: An EEG study.iScience · 2026Article
- Aging shifts hippocampal reactivation from selective reinstatement to category-level misbinding during episodic memory.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- The conceptual relatedness of post-encoding interference influences forgetting for central details in complex memories.Memory & cognition · 2026Article
- Dopaminergic mechanisms supporting hippocampal postencoding dynamics in humans.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Neural correlates and reinstatement of recent and remote memory in children and young adults.eLife · 2025Article
- The intrinsic time tracker: temporal context is embedded in entorhinal and hippocampal functional connectivity patterns.Nature communications · 2025Article
- Propofol differentially modulates the consolidation of schema-related and -unrelated memory.iScience · 2025Article
- Spontaneous reinstatement of episodic memories in the developing human brain.bioRxiv : the preprint server for biology · 2025Article
- Prediction Error-Related Memory Enhancement Depends on the Neural State Surrounding the Prediction Error Event.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Reactivation and consolidation of memory traces during post-encoding rest across the adult lifespan.Annals of clinical and translational neurology · 2025Review
- Article
- Brain functional specialization and cooperation in Alzheimer's disease.Brain and behavior · 2024Article
- Information-based TMS to mid-lateral prefrontal cortex disrupts action goals during emotional processing.Nature communications · 2024Article
- Recurring memory reactivation: The offline component of learning.Neuropsychologia · 2024Article
- The dorsomedial prefrontal cortex prioritizes social learning during rest.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Individuals who see the good in the bad engage distinctive default network coordination during post-encoding rest.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Disruption of Anterior Temporal Lobe Reduces Distortions in Memory From Category Knowledge.Journal of cognitive neuroscience · 2023Article
- Neurofunctional underpinnings of individual differences in visual episodic memory performance.Nature communications · 2023Article
- Effects of schema on the relationship between post-encoding brain connectivity and subsequent durable memory.Scientific reports · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Stable representations of past experience are thought to depend on processes that unfold after events are initially encoded into memory. Post-encoding reactivation and hippocampal-cortical interactions are leading candidate mechanisms thought to support memory retention and stabilization across hippocampal-cortical networks. Although putative consolidation mechanisms have been observed during sleep and periods of awake rest, the direct causal contribution of awake consolidation mechanisms to later behavior is unclear, especially in humans. Moreover, it has been argued that observations of putative consolidation processes are epiphenomenal and not causally important, yet there are few tools to test the functional contribution of these mechanisms in humans. Here, we combined transcranial magnetic stimulation (TMS) and fMRI to test the role of awake consolidation processes by targeting hippocampal interactions with lateral occipital cortex (LOC). We applied theta-burst TMS to LOC (and a control site) to interfere with an extended window (approximately 30-50 min) after memory encoding. Behaviorally, post-encoding TMS to LOC selectively impaired associative memory retention compared to multiple control conditions. In the control TMS condition, we replicated prior reports of post-encoding reactivation and memory-related hippocampal-LOC interactions during periods of awake rest using fMRI. However, post-encoding LOC TMS reduced these processes, such that post-encoding reactivation in LOC and memory-related hippocampal-LOC functional connectivity were no longer present. By targeting and manipulating post-encoding neural processes, these findings highlight the direct contribution of awake time periods to episodic memory consolidation. This combined TMS-fMRI approach provides an opportunity for causal manipulations of human memory consolidation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.