Evidence map›Paper›PMID 32735780›Full record

ReviewCell chemical biology2020

Lanthanide-Based Optical Probes of Biological Systems.

Ukrae Cho, James K Chen

Open access · bronzeAbstract readReview
In one paragraph

Review in Cell chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 111 citations in OpenAlex.

  1. Novel AlphaPlex Design Enables Rapid Differentiation ofPathogens (Basel, Switzerland) · 2026
    Article
  2. Fluorescence quenching-based methods for pharmaceutical analysis: a comprehensive review of principles, probes, and applications.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026
    Review
  3. Single Molecule EuJournal of the American Chemical Society · 2026
    Article
  4. DNA-interacting lanthanide complexes with a DOTA-derived dipyrido[3,2-Dalton transactions (Cambridge, England : 2003) · 2026
    Article
  5. Review
  6. Color-tunable luminescent TbCell reports. Physical science · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Development of Time-Resolved Luminescence Measurement Instruments for Biosensing and Bioimaging - An Overview.Measurement : journal of the International Measurement Confederation · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ukrae ChoDepartment of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA. Electronic address: ucho@alumni.stanford.edu.
James K ChenDepartment of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA; Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA; Department of Chemistry, Stanford University, Stanford, CA 94305, USA. Electronic address: jameschen@stanford.edu.
Stanford University · US

Funding

Chemical tools for developmental biologyR35GM127030 · NIGMS · STANFORD UNIVERSITY · PI JAMES K CHEN · 2018 to 2026
$6.3M
NIGMS NIH HHS R35 GM127030
6 · The paper itself

Abstract

The unique photophysical properties of lanthanides, such as europium, terbium, and ytterbium, make them versatile molecular probes of biological systems. In particular, their long-lived photoluminescence, narrow bandwidth emissions, and large Stokes shifts enable experiments that are infeasible with organic fluorophores and fluorescent proteins. The ability of these metal ions to undergo luminescence resonance energy transfer, and photon upconversion further expands the capabilities of lanthanide probes. In this review, we describe recent advances in the design of lanthanide luminophores and their application in biological research. We also summarize the latest detection systems that have been developed to fully exploit the optical properties of lanthanide luminophores. We conclude with a discussion of remaining challenges and new frontiers in lanthanide technologies. The unprecedented levels of sensitivity and multiplexing afforded by rare-earth elements illustrate how chemistry can enable new approaches in biology.

Indexed as

AnimalsCoordination ComplexesFluorescence Resonance Energy TransferFluorescent DyesLanthanoid Series ElementsMicroscopy, FluorescenceNanoparticlesOptical ImagingProteinsCoordination ComplexesFluorescent DyesLanthanoid Series ElementsProteinschelatesenergy transferimaginglanthanidesluminescence resonancemicroscopynanoparticlesphotoluminescencephotometryphoton upconversion

Identifiers

PMID32735780
PMCPMC7484113
OpenAlexW3046092844

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.