ArticleBiophysical journal2020
Dynamics of Cell Membrane Permeabilization by Saponins Using Terahertz Attenuated Total Reflection.
Article in Biophysical journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Biological Roles of Melanin and Natural Product-Derived Approaches for Its Modulation.International journal of molecular sciences · 2026Review
- Development and optimization of host DNA depletion in blood cultures using a saponin and salt-activated nuclease-based method.Frontiers in microbiology · 2026Article
- Article
- The Effect of Escin on the Plasma Membrane of Human Red Blood Cells.International journal of molecular sciences · 2025Article
- Investigation of the Effects of 2.45 GHz Near-Field EMF on Yeast.Antioxidants (Basel, Switzerland) · 2025Article
- Overcoming fixation and permeabilization challenges in flow cytometry by optical barcoding and multi-pass acquisition.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2024Article
- Overcoming fixation and permeabilization challenges in flow cytometry by optical barcoding and multi-pass acquisition.bioRxiv : the preprint server for biology · 2024Article
- Cell organelles are retained inside pyroptotic corpses during inflammatory cell death.Bioscience reports · 2023Article
- Terahertz Spectroscopy Sheds Light on Real-Time Exchange Kinetics Occurring through Plasma Membrane during Photodynamic Therapy Treatment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- High-sensitivity polarization-independent terahertz Taichi-like micro-ring sensors based on toroidal dipole resonance for concentration detection of Aβ protein.Nanophotonics (Berlin, Germany) · 2023Article
- Saponins: Research Progress and Their Potential Role in the Post-COVID-19 Pandemic Era.Pharmaceutics · 2023Review
- Optimization of protocols for pre-embedding immunogold electron microscopy of neurons in cell cultures and brains.Molecular brain · 2021Article
- Hemoglobin Precipitation: An Index ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
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Authors and funding
2 authors.
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Abstract
Understanding the relevant parameters of the formation of pores during permeabilization is very challenging for medical applications. Several components are involved: the arrival of the permeabilizing molecules to the membrane, the efficiency of formation of the pores and their specific dynamics, and the flux of molecules through the plasma membrane. Using attenuated total reflection in the terahertz domain, we studied the dynamics of Madine-Darby canine kidney cells after permeabilization by saponin molecules. We developed an analytical model taking into account saponin molecule diffusion, cell geometry, cytosol molecule diffusion, and pore dynamics. We also studied the effect of possible pore overlapping on the cell membrane, introducing a dimensionless quantity that is the ratio between overlapping and diffusive effects. Pores are found to be static within 1 h after their creation, hinting that the diffusion of the saponin molecules to the membrane is the limiting factor in our experiments.
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