ArticlePLoS biology2020
Zinc protection of fertilized eggs is an ancient feature of sexual reproduction in animals.
Article in PLoS biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Extracellular zinc acts as a dynamic extracellular regulator of fertilization in Xenopus laevis†.Biology of reproduction · 2026Article
- On the genesis and unique functions of zinc neuromodulation.Journal of neurophysiology · 2024Review
- Overdue Calcium Oscillation Causes Polyspermy but Possibly Permits Normal Development in Mouse Eggs.International journal of molecular sciences · 2023Article
- ZneLife · 2023Article
- ZnbioRxiv : the preprint server for biology · 2023Article
- TMEM16A activation for the fast block to polyspermy in the African clawed frog does not require conventional activation of egg PLCs.The Journal of general physiology · 2023Article
- Dynamic zinc fluxes regulate meiotic progression in Caenorhabditis elegans†.Biology of reproduction · 2022Article
- Zinc is a master-regulator of sperm function associated with binding, motility, and metabolic modulation during porcine sperm capacitation.Communications biology · 2022Article
- Metal ion fluxes controlling amphibian fertilization.Nature chemistry · 2021Article
- Role of zinc in female reproduction.Biology of reproduction · 2021Review
Corrections and comments
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Authors and funding
19 authors at 2 institutions in 1 country.
Funding
Abstract
One of the earliest and most prevalent barriers to successful reproduction is polyspermy, or fertilization of an egg by multiple sperm. To prevent these supernumerary fertilizations, eggs have evolved multiple mechanisms. It has recently been proposed that zinc released by mammalian eggs at fertilization may block additional sperm from entering. Here, we demonstrate that eggs from amphibia and teleost fish also release zinc. Using Xenopus laevis as a model, we document that zinc reversibly blocks fertilization. Finally, we demonstrate that extracellular zinc similarly disrupts early embryonic development in eggs from diverse phyla, including Cnidaria, Echinodermata, and Chordata. Our study reveals that a fundamental strategy protecting human eggs from fertilization by multiple sperm may have evolved more than 650 million years ago.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.