Evidence map›Paper›PMID 32734819›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2020

Differential effects of tobacco cigarettes and electronic cigarettes on endothelial function in healthy young people.

Kacey P Haptonstall, Yasmine Choroomi, Roya Moheimani, Kevin Nguyen, Elizabeth Tran, Karishma Lakhani, Isabella Ruedisueli, Jeffrey Gornbein, Holly R Middlekauff

2 registry-linked trialsOpen access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05595915 phase1 / phase2completednot on this mapstarted 2023, after this paper: background citation

The Effect of Daily COMP-4 Supplementation on Brachial Artery Flow Mediated Dilation and Cellular Senescence Markers in Young and Healthy Individuals

TypeinterventionalSponsorUniversity of California, Los AngelesRan2023 to 2025Enrolled32ConditionsAging, Endothelial Dysfunction, SenescenceArmsCOMP-4
NCT07469475 phase1 / phase2active not recruitingnot on this mapstarted 2026, after this paper: background citation

Effect of a Daily Nitric Oxide-Stimulating Supplement on Plasma PAI-1 Levels: a Six-Week, Open-Label Clinical Trial

TypeinterventionalSponsorUniversity of California, Los AngelesRan2026 to 2026Enrolled35ConditionsAging, Endothelial Dysfunction, SenescenceArmsSupplement with ginger extract, L-citrulline, Paullinia cupana, and muira puama
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.

  1. Comparison of Acute Effects of E-cigarettes With and Without Nicotine and Tobacco Cigarettes on Hemodynamic and Endothelial Parameters: A Systematic Review and Meta-analysis.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2024
    Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Observational
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Kacey P HaptonstallDivision of Cardiology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, California.
Yasmine ChoroomiDivision of Cardiology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, California.
Roya MoheimaniDivision of Cardiology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, California.
Kevin NguyenDivision of Cardiology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, California.ORCID 0000-0002-8327-268X
Elizabeth TranDivision of Cardiology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, California.
Karishma LakhaniDivision of Cardiology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, California.
Isabella RuedisueliDivision of Cardiology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, California.
Jeffrey GornbeinDepartments of Medicine and Computational Medicine, David Geffen School of Medicine at University of California, Los Angeles, California.
Holly R MiddlekauffDivision of Cardiology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, California.
University of California, Los Angeles · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
HHS | NIH | National Center for Advancing Translational Sciences (NCATS) UL1TR001881NCATS NIH HHS UL1 TR001881
6 · The paper itself

Abstract

Tobacco cigarette (TC) smoking has never been lower in the United States, but electronic cigarette (EC) vaping has reached epidemic proportions among our youth. Endothelial dysfunction, as measured by flow-mediated vasodilation (FMD) is a predictor of future atherosclerosis and adverse cardiovascular events and is impaired in young TC smokers, but whether FMD is also reduced in young EC vapers is uncertain. The aim of this study in otherwise healthy young people was to compare the effects of acute and chronic tobacco cigarette (TC) smoking and electronic cigarette (EC) vaping on FMD. FMD was compared in 47 nonsmokers (NS), 49 chronic EC vapers, and 40 chronic TC smokers at baseline and then after EC vapers (

Indexed as

Electronic Nicotine Delivery SystemsVasodilationAdultAtherosclerosisBrachial ArteryCigarette SmokingConsumer Product SafetyCross-Over StudiesE-Cigarette VaporEndothelium, VascularFemaleHealthy VolunteersHumansMaleMiddle AgedRandom AllocationE-Cigarette Vaporelectronic cigarettesendothelial functionflow-mediated dilationnicotinetobacco cigarettes

Identifiers

PMID32734819
PMCPMC7509270
OpenAlexW3046892187

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.