ArticleClinical and experimental otorhinolaryngology2021
Three-Dimensional Distribution of Cochlear Macrophages in the Lateral Wall of Cleared Cochlea.
Article in Clinical and experimental otorhinolaryngology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- The inner ear immune microenvironment in sensorineural hearing loss: mechanisms and therapeutic perspectives.Frontiers in immunology · 2026Review
- Article
- Tissue engineering strategies for spiral ganglion neuron protection and regeneration.Journal of nanobiotechnology · 2024Review
- The Stria Vascularis: Renewed Attention on a Key Player in Age-Related Hearing Loss.International journal of molecular sciences · 2024Review
- Three-dimensional mouse cochlea imaging based on the modified Sca/eS using confocal microscopy.Anatomical science international · 2023Article
- Identification and Characterization of TMEM119-Positive Cells in the Postnatal and Adult Murine Cochlea.Brain sciences · 2023Article
- Inflammatory Monocytes Infiltrate the Spiral Ligament and Migrate to the Basilar Membrane After Noise Exposure.Clinical and experimental otorhinolaryngology · 2022Article
- Tumor necrosis factor-α mediated inflammation versus apoptosis in age-related hearing loss.Frontiers in aging neuroscience · 2022Article
- The Time Course of Monocytes Infiltration After Acoustic Overstimulation.Frontiers in cellular neuroscience · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectivesResident macrophages are well known to be present in the cochlea, but the exact patterns thereof in spiral ligaments have not been discussed in previous studies. We sought to document the distribution of macrophages in intact cochleae using three-dimensional imaging.
methodsCochleae were obtained from C-X3-C motif chemokine receptor 1+/GFP mice, and organ clearing was performed. Three-dimensional images of cleared intact cochleae were reconstructed using two-photon microscopy. The locations of individual macrophages were investigated using 100-μm stacked images to reduce bias. Cochlear inflammation was then induced by lipopolysaccharide (LPS) inoculation into the middle ear through the tympanic membrane. Four days after inoculation, three-dimensional images were obtained.
resultsMacrophages were scarce in areas adjacent to the stria vascularis, particularly the area just beneath it even though many have suspected macrophages to be abundant in this area. This finding remained consistent upon LPS-induced cochlear inflammation, despite a significant increase in the number of macrophages, compared to non-treated cochlea.
conclusionResident macrophages in spiral ligaments are scarce in areas adjacent to the stria vascularis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.