Evidence map›Paper›PMID 32734496›Full record

ArticleThe international journal of cardiovascular imaging2021

Myocardial strain indices and coronary flow reserve are only mildly affected in healthy hypertensive patients.

Dimitrios Evangelou, Aris Bechlioulis, Georgios Tzeltzes, Lampros Lakkas, Ioanna Theodorou, Rigas Kalaitzidis, Evangelia Dounousi, Lampros K Michalis, Katerina K Naka

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Article in The international journal of cardiovascular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Endothelial Function Biomarkers in Hypertension.Current medicinal chemistry · 2025
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Dimitrios Evangelou *2nd Department of Cardiology, University of Ioannina Medical School, University Campus, 45110, Ioannina, Greece.
Aris Bechlioulis *2nd Department of Cardiology, University of Ioannina Medical School, University Campus, 45110, Ioannina, Greece.ORCID http://orcid.org/0000-0003-1721-2539
Georgios Tzeltzes2nd Department of Cardiology, University of Ioannina Medical School, University Campus, 45110, Ioannina, Greece.
Lampros Lakkas2nd Department of Cardiology, University of Ioannina Medical School, University Campus, 45110, Ioannina, Greece.
Ioanna TheodorouDepartment of Nephrology, University Hospital of Ioannina, Ioannina, Greece.
Rigas KalaitzidisDepartment of Nephrology, University Hospital of Ioannina, Ioannina, Greece.
Evangelia DounousiDepartment of Nephrology, University Hospital of Ioannina, Ioannina, Greece.
Lampros K Michalis2nd Department of Cardiology, University of Ioannina Medical School, University Campus, 45110, Ioannina, Greece.
Katerina K Naka2nd Department of Cardiology, University of Ioannina Medical School, University Campus, 45110, Ioannina, Greece. anaka@uoi.gr.ORCID http://orcid.org/0000-0002-9900-9659
University of Ioannina · GRUniversity Hospital of Ioannina · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To investigate changes in two-dimensional myocardial strain echocardiography (2DSTE) indices following a dipyridamole stress test (DIPSE) in relatively healthy hypertensive patients and healthy controls. Forty-seven male hypertensive patients (aged 57±9 years) with normal ejection fraction and without left ventricular (LV) hypertrophy and 20 healthy male subjects were studied with conventional and 2DSTE echocardiography at rest and post DIPSE. Coronary flow reserve (CFR) in the left anterior descending artery following DIPSE was also evaluated. Global longitudinal strain (GLS) and TWIST were higher while UNTWIST rate was lower in hypertensives versus controls (p < 0.05 for all); TWIST remained higher in hypertensives (p = 0.021) after adjustment for differences in age and body mass index (BMI) between the groups. CFR was higher in controls compared to hypertensives even after adjustment for confounders (4.14 vs. 2.53, p = 0.001). DIPSE-induced changes did not differ between the groups after adjustment for age and BMI (p > 0.05 for all). DIPSE-induced improvement in GLS was associated with higher CFR only in hypertensive patients (r - 0.372, p = 0.010). The current study showed that well controlled hypertensive patients have only mild echocardiographic differences compared to controls; some of these differences appear to depend on age and BMI. A 'hyper-rotation' phenomenon (i.e. higher TWIST) early in hypertension may be a compensatory mechanism to preserve global systolic LV function. Coronary microcirculatory function was impaired in hypertensive patients, albeit within normal range, and was associated with DIPSE-induced changes in myocardial long-axis systolic function.

Indexed as

Arterial PressureCoronary CirculationEchocardiography, DopplerEchocardiography, StressMicrocirculationMyocardial ContractionStroke VolumeVentricular Function, LeftAdultAgedBlood Flow VelocityCase-Control StudiesDipyridamoleHeart DiseasesHumansHypertensionDipyridamoleVasodilator AgentsArterial hypertensionCoronary flow reserveDipyridamole stress testMyocardial strainSpeckle tracking

Identifiers

PMID32734496
OpenAlexW3046762446

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.