ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2021
Phenotypic and molecular characterisation of Sporothrix globosa of diverse origin from India.
Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 17 citations in OpenAlex.
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- Cryptic Diversity and Ecological Overlap inJournal of fungi (Basel, Switzerland) · 2025Article
- Sporotrichosis: an overview of the neglected disease reported worldwide in the last five years.Revista da Sociedade Brasileira de Medicina Tropical · 2025Review
- Analyses of the Genetic Diversity and Population Structures ofJournal of fungi (Basel, Switzerland) · 2024Article
- Sporotrichosis in Argentina: clinical and epidemiological analysisBiomedica : revista del Instituto Nacional de Salud · 2023Article
- Phenotypic and Genotypic Characterization and Antifungal Susceptibility ofJournal of fungi (Basel, Switzerland) · 2023Article
- High-Throughput Microsatellite Markers Development for Genetic Characterization of EmergingJournal of fungi (Basel, Switzerland) · 2023Article
- Sporotrichosis: In silico design of new molecular markers for the Sporothrix genus.Revista da Sociedade Brasileira de Medicina Tropical · 2023Article
- Trends in Molecular Diagnostics and Genotyping Tools Applied for EmergingJournal of fungi (Basel, Switzerland) · 2022Review
- Current Progress on Epidemiology, Diagnosis, and Treatment of Sporotrichosis and Their Future Trends.Journal of fungi (Basel, Switzerland) · 2022Review
- Biological and Clinical Attributes ofInfection and drug resistance · 2022Review
- Trends in the molecular epidemiology and population genetics of emergingStudies in mycology · 2021Article
- Special issue on sporotrichosis: challenges to deal with the new emerging pathogenic species.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Fixed Cutaneous Sporotrichosis Due toClinical, cosmetic and investigational dermatology · 2021Article
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sporotrichosis is one of the neglected tropical diseases causing subcutaneous chronic granulomatous lesion by thermally dimorphic fungi belonging to Sporothrix species. Sporothrix brasiliensis, Sporothrix mexicana and Sporothrix globosa are the common pathogenic species. In Asian countries, S. globosa constitutes nearly 99.3% of all Sporothrix species. We studied 63 cases of sporotrichosis of geographically diverse origin from India and Sporothrix isolates were characterised for its growth in different media, temperatures, ability to assimilate sugars and antifungal susceptibility profile. Molecular characterization was performed by sequencing of the calmodulin (CAL), beta tubulin (BT) and translational elongation factor 1-alpha (TEF-1α) and typing by fluorescent amplified fragment length polymorphism (FAFLP). In patients who presented with fixed (49.2%), lymphocutaneous lesions (23.8%), in 26.9% the details were not known, none had systemic dissemination. All the isolates tested were Sporothrix globosa and that could grow up to 35 °C and unable to grow at and beyond 37 °C. The assimilation of sucrose, ribitol and raffinose helps in identifying S. globosa. Sequences of CAL or BT or TEF-1α can differentiate S. globosa from other species in the complex. FAFLP results exhibited low genetic diversity. No correlation was noted between genotypes and clinical presentation, or geographic distribution. Itraconazole, terbinafine and posaconazole showed good in vitro antifungal activity against S. globosa whereas fluconazole and micafungin had no activity. S. globosa of Indian origin is relatively less pathogenic than other pathogenic Sporothrix species as it does not cause systemic dissemination and in the diagnostic laboratory, incubation of the cultures below 37 °C is essential for effective isolation.
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