Evidence map›Paper›PMID 32734464›Full record

ArticleEuropean geriatric medicine2020

Presenting features of COVID-19 in older people: relationships with frailty, inflammation and mortality.

Paul Knopp, Amy Miles, Thomas E Webb, Benjamin C Mcloughlin, Imran Mannan, Nadia Raja, Bettina Wan, Daniel Davis

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European geriatric medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 6 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 6 syntheses or guidelines pooled it, 71 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Paul KnoppDepartment of Medicine for the Elderly, University College London Hospitals NHS Foundation Trust, 1-19 Torrington Place, London, WC1E 7HB, UK.ORCID http://orcid.org/0000-0003-4356-1927
Amy MilesDepartment of Medicine for the Elderly, University College London Hospitals NHS Foundation Trust, 1-19 Torrington Place, London, WC1E 7HB, UK.ORCID http://orcid.org/0000-0002-9008-4599
Thomas E WebbDepartment of Medicine for the Elderly, University College London Hospitals NHS Foundation Trust, 1-19 Torrington Place, London, WC1E 7HB, UK.ORCID http://orcid.org/0000-0003-4660-2341
Benjamin C McloughlinDepartment of Medicine for the Elderly, University College London Hospitals NHS Foundation Trust, 1-19 Torrington Place, London, WC1E 7HB, UK.ORCID http://orcid.org/0000-0002-8691-0675
Imran MannanDepartment of Medicine for the Elderly, University College London Hospitals NHS Foundation Trust, 1-19 Torrington Place, London, WC1E 7HB, UK.ORCID http://orcid.org/0000-0001-5019-5027
Nadia RajaDepartment of Medicine for the Elderly, University College London Hospitals NHS Foundation Trust, 1-19 Torrington Place, London, WC1E 7HB, UK.
Bettina WanDepartment of Medicine for the Elderly, University College London Hospitals NHS Foundation Trust, 1-19 Torrington Place, London, WC1E 7HB, UK.
Daniel DavisDepartment of Medicine for the Elderly, University College London Hospitals NHS Foundation Trust, 1-19 Torrington Place, London, WC1E 7HB, UK. daniel.davis@ucl.ac.uk.ORCID http://orcid.org/0000-0002-1560-1955
University College London Hospitals NHS Foundation Trust · GB

Funding

Wellcome Trust 107467/Z/15/ZWellcome Trust WT107467
6 · The paper itself

Abstract

purposeTo describe the clinical features of COVID-19 in older adults, and relate these to outcomes.

methodsA cohort study of 217 individuals (median age 80, IQR 74-85 years; 62% men) hospitalised with COVID-19, followed up for all-cause mortality, was conducted. Secondary outcomes included cognitive and physical function at discharge. C-reactive protein and neutrophil:lymphocyte ratio were used as measures of immune activity.

resultsCardinal COVID-19 symptoms (fever, dyspnoea, cough) were common but not universal. Inflammation on hospitalisation was lower in frail older adults. Fever, dyspnoea, delirium and inflammation were associated with mortality. Delirium at presentation was an independent risk factor for cognitive decline at discharge.

conclusionsCOVID-19 may present without cardinal symptoms as well as implicate a possible role for age-related changes in immunity in mediating the relationship between frailty and mortality.

Indexed as

COVID-19Accidental FallsAgedAged, 80 and overDeliriumDyspneaFemaleFrailtyHospitalizationHumansInflammationMaleRisk FactorsSARS-CoV-2COVID-19EpidemiologyImmune dysfunctionMortalityPost-hospitalisation outcomes

Identifiers

PMID32734464
PMCPMC7391232
OpenAlexW3045791048

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.