Evidence map›Paper›PMID 32734437›Full record

SynthesisBrain imaging and behavior2021

Challenges and opportunities for neuroimaging in young patients with traumatic brain injury: a coordinated effort towards advancing discovery from the ENIGMA pediatric moderate/severe TBI group.

Emily L Dennis, Karen Caeyenberghs, Robert F Asarnow, Talin Babikian, Brenda Bartnik-Olson, Erin D Bigler, Anthony Figaji, Christopher C Giza, Naomi J Goodrich-Hunsaker, Cooper B Hodges and 21 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Brain imaging and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Structural equation modeling of findings in pediatric tele-neuroradiology: a 2-year nationwide study of turnaround time predictors and clinical decision support.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026
    Article
  5. Review
  6. Article
  7. Review
  8. An update on pediatric traumatic brain injury.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Emily L DennisTBI and Concussion Center, Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA. emily.dennis@hsc.utah.edu.ORCID http://orcid.org/0000-0001-7112-4009
Karen CaeyenberghsCognitive Neuroscience Unit, School of Psychology, Deakin University, Geelong, Australia.
Robert F AsarnowDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, USA.
Talin BabikianDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, USA.
Brenda Bartnik-OlsonDepartment of Radiology, Loma Linda University Medical Center, Loma Linda, CA, USA.
Erin D BiglerTBI and Concussion Center, Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Anthony FigajiDivision of Neurosurgery, University of Cape Town, Cape Town, South Africa.
Christopher C GizaUCLA Steve Tisch BrainSPORT Program, Los Angeles, CA, USA.
Naomi J Goodrich-HunsakerTBI and Concussion Center, Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Cooper B HodgesTBI and Concussion Center, Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Kristen R HoskinsonCenter for Biobehavioral Health, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
Marsh KönigsEmma Children's Hospital, Amsterdam UMC, University of Amsterdam, Emma Neuroscience Group, Amsterdam, The Netherlands.
Harvey S LevinH. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA.
Hannah M LindseyTBI and Concussion Center, Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Abigail LivnyDepartment of Diagnostic Imaging, Sheba Medical Center, Ramat Gan, Tel-Hashomer, Israel.
Jeffrey E MaxDepartment of Psychiatry, University of California, La Jolla, San Diego, CA, USA.
Tricia L MerkleyTBI and Concussion Center, Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Mary R NewsomeH. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA.
Alexander OlsenDepartment of Psychology, Norwegian University of Science and Technology, Trondheim, Norway.
Nicholas P RyanCognitive Neuroscience Unit, School of Psychology, Deakin University, Geelong, Australia.
Matthew S SpruiellH. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA.
Stacy J SuskauerKennedy Krieger Institute, Baltimore, MD, USA.
Sophia I ThomopoulosImaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, Los Angeles, CA, USA.
Ashley L WareDepartment of Psychology, University of Calgary, Calgary, Alberta, Canada.
Christopher G WatsonDepartment of Pediatrics, Children's Learning Institute, University of Texas Health Science Center at Houston, Houston, TX, USA.
Anne L WheelerHospital for Sick Children, Neuroscience and Mental Health Program, Toronto, Canada.
Keith Owen YeatesDepartment of Psychology, University of Calgary, Calgary, Alberta, Canada.
Brandon A ZielinskiTBI and Concussion Center, Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Paul M ThompsonImaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, Los Angeles, CA, USA.
David F TateTBI and Concussion Center, Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Elisabeth A WildeTBI and Concussion Center, Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.

Funding

TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TOGA, ARTHUR W · 2012 to 2022
$14.1M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
Trauma and Genomics Modulate Brain Structure across Common Psychiatric DisordersR01MH111671 · NIMH · DUKE UNIVERSITY · PI MARK W LOGUE, RAJENDRA A MOREY · 2017 to 2026
$4.4M
Magnetoencephalography and Neurobehavioral Outcome of Pediatric Traumatic Brain InjuryR01HD088438 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MAX, JEFFREY EDWIN · 2017 to 2021
$3.1M
ENIGMA-SD: Understanding Sex Differences in Global Mental Health through ENIGMAR01MH116147 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2021
$2.5M
White Matter Damage in Subconcussive Blast ExposureR01NS086885 · NINDS · DUKE UNIVERSITY · PI MOREY, RAJENDRA A · 2014 to 2018
$1.7M
ENIGMA World Aging CenterR56AG058854 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2018
$683k
Longitudinal Tracking of Traumatic Brain Injury: Advanced ConnectomicsK99NS096116 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DENNIS, EMILY LARSEN · 2016 to 2017
$176k
National Institute of Child Health and Human Development HD088438NIA NIH HHS R56 AG058854NIBIB NIH HHS P41 EB015922NIBIB NIH HHS U54 EB020403NICHD NIH HHS R01 HD088438NIH HHS U54 EB020403, R01 MH116147, R56 AG058854, P41 EB015922, R01 MH111671NIMH NIH HHS R01 MH111671NIMH NIH HHS R01 MH116147NINDS NIH HHS K99 NS096116NINDS NIH HHS NS096116NINDS NIH HHS R01 NS086885
6 · The paper itself

Abstract

Traumatic brain injury (TBI) is a major cause of death and disability in children in both developed and developing nations. Children and adolescents suffer from TBI at a higher rate than the general population, and specific developmental issues require a unique context since findings from adult research do not necessarily directly translate to children. Findings in pediatric cohorts tend to lag behind those in adult samples. This may be due, in part, both to the smaller number of investigators engaged in research with this population and may also be related to changes in safety laws and clinical practice that have altered length of hospital stays, treatment, and access to this population. The ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Pediatric Moderate/Severe TBI (msTBI) group aims to advance research in this area through global collaborative meta-analysis of neuroimaging data. In this paper, we discuss important challenges in pediatric TBI research and opportunities that we believe the ENIGMA Pediatric msTBI group can provide to address them. With the paucity of research studies examining neuroimaging biomarkers in pediatric patients with TBI and the challenges of recruiting large numbers of participants, collaborating to improve statistical power and to address technical challenges like lesions will significantly advance the field. We conclude with recommendations for future research in this field of study.

Indexed as

Brain Injuries, TraumaticMagnetic Resonance ImagingAdolescentAdultBiomarkersChildHumansNeuroimagingBiomarkersENIGMAModerate-severe TBINeuroimagingPediatrictraumatic brain injury (TBI)

Identifiers

PMID32734437
PMCPMC7855317

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.