SynthesisJournal of autism and developmental disorders2021
The Emergence of Autism Symptoms Prior to 18 Months of Age: A Systematic Literature Review.
Synthesis in Journal of autism and developmental disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Parental Perspectives on Early Life Screening and Genetic Testing for ASD: A Systematic Review.Journal of autism and developmental disorders · 2025Pooled it
- Effects of Parent-Implemented Interventions on Outcomes of Children with Autism: A Meta-Analysis.Journal of autism and developmental disorders · 2023Pooled it
- Efficacy of very early interventions on neurodevelopmental outcomes for infants and toddlers at increased likelihood of or diagnosed with autism: A systematic review and meta-analysis.Autism research : official journal of the International Society for Autism Research · 2023Pooled it
- In Search of Subtypes of Children With Developmental Disabilities Using the WISC-V: A Latent Profile Analysis.Journal of autism and developmental disorders · 2026Article
- Social regression stems from a latent phase of GABAergic dysfunction and sensory breakdown in a model of synaptopathy.Molecular psychiatry · 2026Article
- Somali and Eritrean parents experiences and challenges in the diagnosis and early intervention of autism spectrum disorder in Norway.BMC pediatrics · 2026Article
- Early Neurodevelopmental Milestones in Children With Autism Spectrum Disorder: A Retrospective Observational Study.Cureus · 2025Article
- Narrative review of neurodevelopmental and psychiatric complications associated with prematurity.BMC pediatrics · 2025Review
- Gut and Metabolic Biomarkers in Autism Spectrum Disorder: A Systematic Review of Body Fluid Signatures for Early Detection.Journal of autism and developmental disorders · 2025Article
- Caregiver Perspectives on the Use of Tele-Assessment for Toddlers with Developmental Concerns.Journal of autism and developmental disorders · 2025Article
- Sleep Disorders in Children with Autism Spectrum Disorder: Developmental Impact and Intervention Strategies.Brain sciences · 2025Review
- Article
- Families' and clinicians' experiences with telehealth assessments for autism: A mixed-methods systematic review.PLOS digital health · 2025Article
- Evaluating canonical babbling ratios extracted from day-long audio recordings in infants later diagnosed with autism spectrum disorder.Infant behavior & development · 2025Article
- The Use of Griffiths III in the Appraisal of the Developmental Profile in Autism: A Systematic Search and Review.Brain sciences · 2025Review
- Autism common variants associated with white matter alterations at birth: cross-sectional fixel-based analyses of 221 European term-born neonates from the developing human connectome project.Translational psychiatry · 2025Article
- Sensory-movement underpinnings of lifelong neurodivergence: getting a grip on autism.Frontiers in integrative neuroscience · 2025Article
- HERVs Endophenotype in Autism Spectrum Disorder: Human Endogenous Retroviruses, Specific Immunoreactivity, and Disease Association in Different Family Members.Microorganisms · 2024Review
- Developmental trajectories in infants and pre-school children with Neurofibromatosis 1.Molecular autism · 2024Article
- Association between rare, genetic variants linked to autism and ultrasonography fetal anomalies in children with autism spectrum disorder.Journal of neurodevelopmental disorders · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pre-diagnostic intervention for autism spectrum disorder (ASD) allows symptoms to be addressed as they emerge, often between six to 18 months, rather than after the full onset of the disorder. A systematic literature review, spanning the previous six years was conducted in order to provide an updated review looking at the earliest behavior symptoms of ASD. All included studies used a prospective experimental design, reported on symptoms that emerged before 18-months of age, exclusively in children who would later receive a diagnosis, and were assessed for quality. This review is the first to address this research question through the use of a systematic research design and extends the literature by following up on recommendations for future research from previous findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.