Evidence map›Paper›PMID 32734421›Full record

ArticleJournal of autism and developmental disorders2021

Assessing Irritability in Children with Autism Spectrum Disorder Using the Affective Reactivity Index.

Carla B Kalvin, Theresa R Gladstone, Rebecca Jordan, Sonia Rowley, Carolyn L Marsh, Karim Ibrahim, Denis G Sukhodolsky

Registry-linked trialAbstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04654260 (Behavior Therapy for Irritability and Aggression in Adolescents With Autism), which is not on this map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04654260 nacompletednot on this map

Behavior Therapy for Irritability and Aggression in Adolescents With Autism

TypeinterventionalSponsorYale UniversityRan2020 to 2026Enrolled65ConditionsAutism Spectrum Disorder, Irritability, Disruptive Behavior, AngerArmsBehavioral Therapy for Irritability in Autism, Psychoeducation and Supportive Therapy (PST)
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  12. Strategies for optimal management of pediatric acute agitation in emergency settings.Journal of the American College of Emergency Physicians open · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Carla B KalvinChild Study Center, Yale University School of Medicine, 230 S. Frontage Road, New Haven, CT, 06520, USA. carla.kalvin@yale.edu.ORCID http://orcid.org/0000-0002-5775-0131
Theresa R GladstoneChild Study Center, Yale University School of Medicine, 230 S. Frontage Road, New Haven, CT, 06520, USA.
Rebecca JordanChild Study Center, Yale University School of Medicine, 230 S. Frontage Road, New Haven, CT, 06520, USA.
Sonia RowleyChild Study Center, Yale University School of Medicine, 230 S. Frontage Road, New Haven, CT, 06520, USA.
Carolyn L MarshChild Study Center, Yale University School of Medicine, 230 S. Frontage Road, New Haven, CT, 06520, USA.
Karim IbrahimChild Study Center, Yale University School of Medicine, 230 S. Frontage Road, New Haven, CT, 06520, USA.
Denis G SukhodolskyChild Study Center, Yale University School of Medicine, 230 S. Frontage Road, New Haven, CT, 06520, USA. denis.sukhodolsky@yale.edu.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Multimodal Developmental Neurogenetics of Females with ASDR01MH100028 · NIMH · YALE UNIVERSITY · PI Allison Elizabeth Jack, LAUREN KENWORTHY · 2012 to 2026
$37.8M
TRAINING PROGRAM IN CHILDHOOD NEUROPSYCHIATRIC DISORDERST32MH018268 · NIMH · YALE UNIVERSITY · PI Michael H Bloch, MICHAEL J CROWLEY · 1985 to 2026
$11.0M
NRSA Training CoreTL1TR001864 · NCATS · YALE UNIVERSITY · PI CANTLEY, LLOYD G, EDELMAN, E. JENNIFER · 2016 to 2025
$9.9M
Neural Mechanisms of CBT for Anxiety in Children with Autism Spectrum DisorderR01HD083881 · NICHD · YALE UNIVERSITY · PI PELPHREY, KEVIN A, SUKHODOLSKY, DENIS G · 2016 to 2020
$2.8M
Using CBT to examine circuitry of frustrative non-reward in aggressive childrenR01MH101514 · NIMH · YALE UNIVERSITY · PI PELPHREY, KEVIN A, SUKHODOLSKY, DENIS G · 2013 to 2016
$1.8M
NCATS NIH HHS TL1 TR001864NCATS NIH HHS UL1 TR001863NICHD NIH HHS R01 HD083881NIH HHS T32 MH18268NIMH NIH HHS R01 MH100028NIMH NIH HHS R01 MH101514NIMH NIH HHS T32 MH018268
6 · The paper itself

Abstract

Irritability is an impairing problem in children with ASD that may be associated with other behavioral and emotional concerns. The Affective Reactivity Index (ARI) is a parent-rated measure of irritability widely used in children with mood disorders, however, its utility in children with ASD remains unclear. In this study, we examined ARI parent ratings in children with ASD and contributions of parent-rated anxiety and noncompliance to irritability measured by the ARI. Participants included 81 children with ASD, aged 8-16 years. Results suggest that both anxiety and noncompliance contribute to irritability, but that anxiety only contributes to irritability in the absence of noncompliance. Further, the ARI is likely to be a useful measure of irritability in children with ASD.

Indexed as

AdolescentAffective SymptomsAnxietyAutism Spectrum DisorderChildCross-Sectional StudiesFemaleHumansIrritable MoodMaleMood DisordersParentsSurveys and QuestionnairesAnxietyAutism spectrum disorderIrritabilityNoncompliance

Identifiers

PMID32734421
PMCPMC7855357

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.