Evidence map›Paper›PMID 32734370›Full record

ArticleAnnals of surgical oncology2020

Changing the Default: A Prospective Study of Reducing Discharge Opioid Prescription after Lumpectomy and Sentinel Node Biopsy.

Tracy-Ann Moo, Kate R Pawloski, Varadan Sevilimedu, Jillian Charyn, Brett A Simon, Lisa M Sclafani, George Plitas, Andrea V Barrio, Laurie J Kirstein, Kimberly J Van Zee and 1 more

Open access · greenAbstract read
In one paragraph

Article in Annals of surgical oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Tracy-Ann MooBreast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Kate R PawloskiBreast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Varadan SevilimeduBiostatistics Service, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Jillian CharynBreast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Brett A SimonDepartment of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Lisa M SclafaniBreast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
George PlitasBreast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Andrea V BarrioBreast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Laurie J KirsteinBreast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Kimberly J Van ZeeBreast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Monica MorrowBreast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA. morrowm@mskcc.org.
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748NIH/NCI Cancer Center Support Grant P30Ca008748
6 · The paper itself

Abstract

backgroundWhether routinely prescribed opioids are necessary for pain control after discharge among lumpectomy/sentinel node biopsy (Lump/SLNB) patients is unclear. We hypothesize that Lump/SLNB patients could be discharged without opioids, with a failure rate < 10%. This study prospectively examines outcomes after changing standard discharge prescription from an opioid/non-steroidal anti-inflammatory drug (NSAID) to NSAID/acetaminophen. PATIENTS AND

methodsStandard discharge pain medication orders included opioids in the first 3-month study period and were changed to NSAID/acetaminophen in the second 3-month period. Patient-reported medication consumption and pain scores were collected by post-discharge survey. Frequency of discharge with opioid, NSAID/acetaminophen failure rate, opioid use, and pain scores were examined.

resultsFrom May to October 2019, 663 patients had Lump/SLNB: 371 in the opioid study period and 292 in the NSAID period. In the opioid period, 92% (342/371) of patients were prescribed an opioid at discharge; of 142 patients who documented opioid use on the survey, 86 (61%) used zero tablets. Among 56 (39%) patients who used opioids, the median number taken by POD 5 was 4. After the change to NSAID/acetaminophen, rates of opioid prescription decreased to 14% (41/292). The NSAID/acetaminophen failure rate was 2% (5/251). Among survey respondents, there was no significant difference in the maximum reported pain scores (POD 1-5) between the opioid period and the NSAID period (p = 0.7).

conclusionsIn Lump/SLNB patients, a change to default discharge with NSAID/acetaminophen resulted in a 78% absolute reduction in opioid prescription, with a failure rate of 2% and no difference in patient-reported pain scores. Most Lump/SLNB patients can be discharged with NSAID/acetaminophen.

Indexed as

Patient DischargeAftercareAgedAnalgesics, OpioidBiopsyHumansMastectomy, SegmentalMiddle AgedPostoperative PainPrescriptionsProspective StudiesAnalgesics, Opioid

Identifiers

PMID32734370
PMCPMC7554186
OpenAlexW3045805201

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.