ArticleSocial cognitive and affective neuroscience2020
Resting-state functional connectivity of neural circuits associated with primary and secondary rewards in patients with bipolar disorder.
Article in Social cognitive and affective neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Altered brain activation during reward anticipation in bipolar disorder.Translational psychiatry · 2022Pooled it
- Current analysis of hypoxic-ischemic encephalopathy research issues and future treatment modalities.Frontiers in neuroscience · 2023Review
- Left ventrolateral prefrontal cortical activity during reward expectancy predicts mania risk up to one year post scan.Journal of affective disorders · 2022Article
- Resting-state functional connectivity graph-properties correlate with bipolar disorder-risk in young medication-free depressed subjects: Bipolar-risk Resting State Functional Connectivity in Major Depression.Journal of affective disorders · 2022Article
- Restlessness with manic episodes induced by right-sided multiple strokes after COVID-19 infection: A case report.Brain circulationArticle
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe used resting-state functional connectivity (rsFC) to evaluate the integrity of the neural circuits associated with primary and secondary rewards in bipolar disorder (BD) with different mood phases.
methodsSixty patients with BD [21 patients with depressive episode of BD (BDD) and 41 patients with maniac episode of BD (BDM)] and 42 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging. rsFC was assessed using region of interest-wise analyses.
resultsAttenuation of rsFC at the orbitofrontal cortex (OFC) and the left ventral striatum (LVS) was observed in the secondary reward circuit of patients with BD compared to that of HCs. Among BDD, BDM and HCs, the rsFC between OFC and LVS in BDM was intermediate, while the rsFC between OFC and right ventral striatum/right amygdala in BDM was the highest; the corresponding rsFC values in BDD were the lowest. Furthermore, a positive correlation was found between rsFC and Young Mania Rating Scale scores in BDM.
conclusionsThis study suggests that there may be an abnormal rsFC between OFC and LVS in the second reward of patients with BD and the discrepant patterns of rsFC may exist between different mood states in patients with BD.
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