Evidence map›Paper›PMID 32734275›Full record

ArticleRadiology. Cardiothoracic imaging2020

Reproducibility of Segmentation-based Myocardial Radiomic Features with Cardiac MRI.

Jihye Jang, Long H Ngo, Jennifer Mancio, Selcuk Kucukseymen, Jennifer Rodriguez, Patrick Pierce, Beth Goddu, Reza Nezafat

Abstract read
In one paragraph

Article in Radiology. Cardiothoracic imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. Review
  9. Radiomics for the detection of diffusely impaired myocardial perfusion: A proof-of-concept study using 13N-ammonia positron emission tomography.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  10. Article
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  12. Radiomics and deep learning for myocardial scar screening in hypertrophic cardiomyopathy.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2022
    Article
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  18. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Jihye JangCardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Boston, MA 02215 (J.J., L.H.N., J.M., S.K., J.R., P.P., B.G., R.N.); Department of Computer Science, Technical University of Munich, Munich, Germany (J.J.); and Department of Biostatistics, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Mass (L.H.N.).ORCID 0000-0002-4333-1083
Long H NgoCardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Boston, MA 02215 (J.J., L.H.N., J.M., S.K., J.R., P.P., B.G., R.N.); Department of Computer Science, Technical University of Munich, Munich, Germany (J.J.); and Department of Biostatistics, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Mass (L.H.N.).ORCID 0000-0001-9349-7981
Jennifer MancioCardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Boston, MA 02215 (J.J., L.H.N., J.M., S.K., J.R., P.P., B.G., R.N.); Department of Computer Science, Technical University of Munich, Munich, Germany (J.J.); and Department of Biostatistics, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Mass (L.H.N.).ORCID 0000-0003-0814-6672
Selcuk KucukseymenCardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Boston, MA 02215 (J.J., L.H.N., J.M., S.K., J.R., P.P., B.G., R.N.); Department of Computer Science, Technical University of Munich, Munich, Germany (J.J.); and Department of Biostatistics, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Mass (L.H.N.).
Jennifer RodriguezCardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Boston, MA 02215 (J.J., L.H.N., J.M., S.K., J.R., P.P., B.G., R.N.); Department of Computer Science, Technical University of Munich, Munich, Germany (J.J.); and Department of Biostatistics, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Mass (L.H.N.).
Patrick PierceCardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Boston, MA 02215 (J.J., L.H.N., J.M., S.K., J.R., P.P., B.G., R.N.); Department of Computer Science, Technical University of Munich, Munich, Germany (J.J.); and Department of Biostatistics, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Mass (L.H.N.).
Beth GodduCardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Boston, MA 02215 (J.J., L.H.N., J.M., S.K., J.R., P.P., B.G., R.N.); Department of Computer Science, Technical University of Munich, Munich, Germany (J.J.); and Department of Biostatistics, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Mass (L.H.N.).
Reza NezafatCardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Boston, MA 02215 (J.J., L.H.N., J.M., S.K., J.R., P.P., B.G., R.N.); Department of Computer Science, Technical University of Munich, Munich, Germany (J.J.); and Department of Biostatistics, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Mass (L.H.N.).

Funding

Cardiovascular MRI Characterization of the Arrhythmogenic Heart in Nonischemic CardiomyopathyR01HL129185 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI NEZAFAT, REZA · 2015 to 2024
$6.4M
Gadolinium Free Cardiac MR Imaging of Scar and FibrosisR01HL154744 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI NEZAFAT, REZA · 2020 to 2023
$3.5M
Imaging Markers of Subclinical Cardiotoxicity in Breast CancerR01HL127015 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI NEZAFAT, REZA · 2016 to 2020
$3.5M
Myocardial Tissue Characterization with MR Relaxometry in Heart FailureR01HL129157 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI NEZAFAT, REZA · 2017 to 2020
$3.2M
NHLBI NIH HHS R01 HL127015NHLBI NIH HHS R01 HL129157NHLBI NIH HHS R01 HL129185NHLBI NIH HHS R01 HL154744
6 · The paper itself

Abstract

purposeTo investigate reproducibility of myocardial radiomic features with cardiac MRI. MATERIALS AND

methodsTest-retest studies were performed with a 3-T MRI system using commonly used cardiac MRI sequences of cine balanced steady-state free precession (cine bSSFP), T1-weighted and T2-weighted imaging, and quantitative T1 and T2 mapping in phantom experiments and 10 healthy participants (mean ± standard deviation age, 29 years ± 13). In addition, this study assessed repeatability in 51 patients (56 years ± 14) who underwent imaging twice during the same session. Three readers independently delineated the myocardium to investigate inter- and intraobserver reproducibility of radiomic features. A total of 1023 radiomic features were extracted by using PyRadiomics (

resultsDifferent reproducibility patterns were observed among sequences in in vivo test-retest studies. In cine bSSFP, the gray-level run-length matrix was the most reproducible feature family, and the wavelet low-pass filter applied horizontally and vertically was the most reproducible image filter. In T1 and T2 maps, intensity-based statistics (first-order) and gray-level co-occurrence matrix features were the most reproducible feature families, without a dominant reproducible image filter. Across all sequences, gray-level nonuniformity was the most frequently identified reproducible feature name. In inter- and intraobserver reproducibility studies, respectively, only 32%-47% and 61%-73% of features were identified as reproducible.

conclusionOnly a small subset of myocardial radiomic features was reproducible, and these reproducible radiomic features varied among different sequences.

Identifiers

PMID32734275
PMCPMC7377242

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.