Evidence map›Paper›PMID 32734236›Full record

ArticleKidney medicine

GFR Estimation Using a Panel of Filtration Markers in Shanghai and Beijing.

Nan Chen, Hao Shi, Luxia Zhang, Li Zuo, Jingyuan Xie, Danshu Xie, Amy B Karger, Shiyuan Miao, Hong Ren, Wen Zhang and 10 more

Open access · goldAbstract read
In one paragraph

Article in Kidney medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Comparison of BTP, NGAL, KIM-1, & ADMA biomarkers in CKD and non-CKD subjects.International journal of biochemistry and molecular biology · 2023
    Article
  6. Article
  7. A New Panel-Estimated GFR, Including βAmerican journal of kidney diseases : the official journal of the National Kidney Foundation · 2021
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 2 countries.

Nan ChenDepartment of Nephrology, Institute of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hao ShiDepartment of Nephrology, Institute of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Luxia ZhangRenal Division, Department of Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, China.
Li ZuoDepartment of Nephrology, Peking University People's Hospital, Beijing, China.
Jingyuan XieDepartment of Nephrology, Institute of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Danshu XieDepartment of Nephrology, Institute of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Amy B KargerDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.
Shiyuan MiaoDivision of Nephrology, Tufts Medical Center, Boston, MA.
Hong RenDepartment of Nephrology, Institute of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wen ZhangDepartment of Nephrology, Institute of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Weiming WangDepartment of Nephrology, Institute of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yujing PanRenal Division, Department of Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, China.
Wei MinjiInstitute of Clinical Pharmacology, Peking University First Hospital, Beijing, China.
Zhun SuiDepartment of Nephrology, Peking University People's Hospital, Beijing, China.
Aghogho OkparaveroDivision of Nephrology, Tufts Medical Center, Boston, MA.
Andrew SimonDivision of Nephrology, Tufts Medical Center, Boston, MA.
Juhi ChaudhariDivision of Nephrology, Tufts Medical Center, Boston, MA.
John H EckfeldtDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.
Lesley A InkerDivision of Nephrology, Tufts Medical Center, Boston, MA.
Andrew S LeveyDivision of Nephrology, Tufts Medical Center, Boston, MA.
Tufts Medical Center · USShanghai Jiao Tong University · CNPeking University · CNPeking University People's Hospital · CNRuijin Hospital · CNUniversity of Minnesota · US

Funding

Estimating GFR from a Panel of Endogenous Filtration Markers (Panel eGFR)R01DK097020 · NIDDK · TUFTS MEDICAL CENTER · PI LEVEY, ANDREW S · 2012 to 2014
$1.9M
NIDDK NIH HHS R01 DK097020
6 · The paper itself

Abstract

RATIONALE &

objectivesEstimated glomerular filtration rate (eGFR) using creatinine and cystatin C (eGFR STUDY

designDiagnostic test study. SETTING &

participants1,066 participants in Shanghai and Beijing with creatinine and cystatin C and 666 participants with all 4 filtration markers. TESTS COMPARED: Index tests were previously developed equations for eGFR using creatinine, cystatin C, B2M, and BTP and combinations. The reference test was mGFR using plasma clearance of iohexol. We compared the performance of eGFR OUTCOMES: Accuracy was significantly better for eGFR LIMITATIONS: Study population may not be generalizable to clinical settings other than large urban medical centers in China.

conclusionsA panel of endogenous filtration markers including B2M and BTP in addition to creatinine and cystatin C may improve GFR estimation in China. Further study is necessary to determine whether GFR estimation using B2M and BTP can be improved and whether these improvements lead to useful clinical applications.

Indexed as

beta-2 microglobulinbeta-trace proteinChinacreatininecystatin CEstimated GFR

Identifiers

PMID32734236
PMCPMC7380432
OpenAlexW3004179849

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.