Evidence map›Paper›PMID 32734226›Full record

ArticleKidney medicine

Nonsurgical Periodontal Therapy in CKD: Findings of the Kidney and Periodontal Disease (KAPD) Pilot Randomized Controlled Trial.

Vanessa Grubbs, Faviola Garcia, Eric Vittinghoff, Bonnie L Jue, Mark Ryder, David H Lovett, Steven Offenbacher, George Taylor, Peter Ganz, Kirsten Bibbins-Domingo and 1 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01802216 (Kidney and Periodontal Disease Study), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01802216 nacompletednot on this map

Kidney and Periodontal Disease Study

TypeinterventionalSponsorUniversity of California, San FranciscoRan2014 to 2017Enrolled51ConditionsChronic Kidney Disease, Periodontal DiseaseArmsScaling and root planing, Minocycline
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Review
  7. Chronic Kidney Disease and Periodontitis Interplay-A Narrative Review.International journal of environmental research and public health · 2023
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Vanessa GrubbsDepartment of Medicine, University of California, San Francisco, CA.
Faviola GarciaDepartment of Medicine, University of California, San Francisco, CA.
Eric VittinghoffDivision of Epidemiology & Biostatistics, University of California, San Francisco, CA.
Bonnie L JueOral Epidemiology & Dental Public Health, Department of Preventive & Restorative Dental Sciences, University of California, San Francisco, CA.
Mark RyderDivision of Periodontology, University of California, San Francisco, CA.
David H LovettDivision of Nephrology, San Francisco Veterans Affairs Medical Center, San Francisco, CA.
Steven OffenbacherDepartment of Periodontology, Center for Oral and Systemic Diseases, UNC School of Dentistry, San Francisco, CA.
George TaylorOral Epidemiology & Dental Public Health, Department of Preventive & Restorative Dental Sciences, University of California, San Francisco, CA.
Peter GanzDivision of Cardiology, University of California, San Francisco, San Francisco, CA.
Kirsten Bibbins-DomingoDivision of Epidemiology & Biostatistics, University of California, San Francisco, CA.
Neil R PoweDepartment of Medicine, University of California, San Francisco, CA.
University of California, San Francisco · USSan Francisco General Hospital · USSan Francisco VA Medical Center · US

Funding

The Role of Periodontal Disease in Chronic Kidney Disease ProgressionK23DK093710 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRUBBS, VANESSA · 2012 to 2016
$1.0M
NIDDK NIH HHS K23 DK093710
6 · The paper itself

Abstract

RATIONALE &

objectiveObservational studies have suggested that periodontal disease may be a modifiable risk factor for chronic kidney disease (CKD). The Kidney and Periodontal Disease (KAPD) Study was designed to determine the feasibility of conducting a periodontal disease treatment trial among a high-risk (mostly poor and racial/ethnic minority) population and estimate the magnitude and variability of kidney and inflammatory biomarker levels in response to intensive periodontal treatment. STUDY

designSingle-center, unmasked, intention-to-treat, randomized, controlled, pilot trial with 2:1 allocation to the treatment and comparison groups. SETTING &

participantsEnglish- and Spanish-speaking individuals aged 20 to 75 years receiving primary care within the San Francisco Community Health Network with evidence of both moderate to severe periodontal disease and CKD.

interventionImmediate intensive nonsurgical periodontal treatment versus rescue treatment for progressive disease at baseline and 4, 8, and 12 months. OUTCOMES: Feasibility and process outcomes. Levels of biomarkers of kidney function, kidney injury, and systemic inflammation obtained at baseline and 4 and 12 months.

resultsKAPD randomly assigned 51 participants to the immediate (34 participants) or rescue (17 participants) groups. 14% dropped out of the study (4 immediate, 3 rescue) and 80% completed all 4 visits of the 12-month protocol (28 immediate, 13 rescue). Fewer than half the teeth recommended for extraction were extracted and 40% of immediate group visits were outside the protocol window. Bleeding on probing and probing depth improved more in the immediate group than in the rescue group; there was no significant separation in periodontal status. Levels of markers of vascular endothelial and systemic injury declined in both groups. LIMITATIONS: No true control group.

conclusionsThis 12-month, pilot, randomized, controlled trial successfully recruited and retained a high-risk population but was less successful observing treatment adherence, treatment effect, and variability of biomarker levels. Although KAPD did not meet all of its goals, important lessons learned can be applied to future studies.

fundingNational Institute of Diabetes and Digestive and Kidney Disease (Bethesda, MD; grant number 1K23DK093710-01A1) and Harold Amos Medical Faculty Development Program of the Robert Wood Johnson Foundation, Princeton, NJ. Funders had no role in study design; collection, analysis, or interpretation of data; writing the report; or the decision to submit the report for publication.

trial registrationNCT01802216.

Indexed as

Chronic kidney diseasenon-surgical periodontal disease treatmentperiodontal diseaseperiodontitis

Identifiers

PMID32734226
PMCPMC7380373
OpenAlexW2992137653

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.