ArticleScience advances2020
High-sensitivity in vivo contrast for ultra-low field magnetic resonance imaging using superparamagnetic iron oxide nanoparticles.
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 97 citations in OpenAlex.
- Open-Source Multinuclear Low-Field Preclinical MRI Scanner.NMR in biomedicine · 2026Article
- Ultra-low fieldCommunications chemistry · 2026Article
- Engineering the Colloidal Properties of Iron Oxide Nanoparticles for HighACS applied nano materials · 2025Article
- Advances in multimodal imaging techniques in nanomedicine: enhancing drug delivery precision.RSC advances · 2025Review
- Enhanced detection of glioblastoma vasculature with superparamagnetic iron oxide nanoparticles and MRI.Scientific reports · 2025Article
- Tips and challenges for clinical use and interpretation of low field portable MRI in neuroimaging.Emergency radiology · 2025Review
- Updates on Methods for Body Composition Analysis: Implications for Clinical Practice.Current obesity reports · 2025Review
- Low-Field (64 mT) Portable MRI for Rapid Point-of-Care Diagnosis of Dissemination in Space in Patients Presenting with Optic Neuritis.AJNR. American journal of neuroradiology · 2024Article
- Identification of SLC31A1 as a prognostic biomarker and a target for therapeutics in breast cancer.Scientific reports · 2024Article
- Enhancing organ and vascular contrast in preclinical ultra-low field MRI using superparamagnetic iron oxide nanoparticles.Communications biology · 2024Article
- Super-resolution neural networks improve the spatiotemporal resolution of adaptive MRI-guided radiation therapy.Communications medicine · 2024Article
- Direct observation of NMR transverse relaxation in nanopatterned clusters of iron oxide particles.Magnetic resonance in medicine · 2024Article
- Research Advances of Lipid Nanoparticles in the Treatment of Colorectal Cancer.International journal of nanomedicine · 2024Review
- Low-field MRI: A report on the 2022 ISMRM workshop.Magnetic resonance in medicine · 2023Review
- Interaction of Nanomaterials with Cells and Tissues.International journal of molecular sciences · 2023Article
- Brain imaging with portable low-field MRI.Nature reviews bioengineering · 2023Article
- Zero- to low-field relaxometry of chemical and biological fluids.Communications chemistry · 2023Article
- Iron oxide nanoparticles as positive TScientific reports · 2023Article
- EnhancedMagnetic resonance in medicine · 2023Article
- Principles and applications of magnetic nanomaterials in magnetically guided bioimaging.Materials today physics · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Magnetic resonance imaging (MRI) scanners operating at ultra-low magnetic fields (ULF; <10 mT) are uniquely positioned to reduce the cost and expand the clinical accessibility of MRI. A fundamental challenge for ULF MRI is obtaining high-contrast images without compromising acquisition sensitivity to the point that scan times become clinically unacceptable. Here, we demonstrate that the high magnetization of superparamagnetic iron oxide nanoparticles (SPIONs) at ULF makes possible relaxivity- and susceptibility-based effects unachievable with conventional contrast agents (CAs). We leverage these effects to acquire high-contrast images of SPIONs in a rat model with ULF MRI using short scan times. This work overcomes a key limitation of ULF MRI by enabling in vivo imaging of biocompatible CAs. These results open a new clinical translation pathway for ULF MRI and have broader implications for disease detection with low-field portable MRI scanners.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.