Evidence map›Paper›PMID 32733898›Full record

ArticleFrontiers in cell and developmental biology2020

The Error-Prone Kinetochore-Microtubule Attachments During Meiosis I in Vitrified Oocytes.

Lei Gao, Yunpeng Hou, Shenming Zeng, Junyou Li, Shien Zhu, Xiangwei Fu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Lei GaoNational Engineering Laboratory for Animal Breeding and Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Yunpeng HouState Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Shenming ZengNational Engineering Laboratory for Animal Breeding and Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Junyou LiAnimal Resource Science Center, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Ibaraki, Japan.
Shien ZhuNational Engineering Laboratory for Animal Breeding and Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Xiangwei FuNational Engineering Laboratory for Animal Breeding and Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing, China.
China Agricultural University · CNThe University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oocytes vitrification is frequently applied in assisted reproductive technologies. However, chromosomes segregation was error-prone during meiosis maturation of vitrified oocytes. The fidelity of chromosomes segregation depends on the correct kinetochore-microtubule attachments (KT-MTs). In meiosis I, the Aurora B/C would not spatially separate from the attachment sites upon bivalents stretched. Oocytes lack a mechanism for coordinating bivalent stretching and Aurora B/C inhibition in meiosis I. Thus, the KT-MTs are unstable in oocytes. In this study, we firstly found the incorrect KT-MTs were markedly increased in vitrified oocytes. The Aurora B/C activity in vitrified oocytes was significantly increased when the bivalents were stretched. This Aurora B/C activity could not induce a SAC response, as the SAC protein Mad2 was significantly decreased during MI stage in vitrified oocytes. Thus, the KT-MTs in vitrified oocytes were error-prone. This study, for the first time, revealed the mechanism of the incorrect KT-MTs occurred in vitrified oocytes and provided a theoretical basis for further improvement of oocytes vitrification.

Indexed as

aurora B/Cbivalent stretchkinetochore-microtubule attachmentoocytes vitrificationspindle assembly checkpoint

Identifiers

PMID32733898
PMCPMC7363986
OpenAlexW3041080491

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.