Evidence map›Paper›PMID 32733643›Full record

ArticleOncotarget2020

Lipid and protein tumor markers for head and neck squamous cell carcinoma identified by imaging mass spectrometry.

Janos Schmidt, Béla Kajtár, Kata Juhász, Mária Péter, Tamás Járai, András Burián, László Kereskai, Imre Gerlinger, Tamás Tornóczki, Gábor Balogh and 3 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

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  10. [Advances of spatial omics in the individualized diagnosis and treatment of head and neck cancer].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2023
    Article
  11. Spatial Lipidomic Profiling of Mouse Joint Tissue Demonstrates the Essential Role of PHOSPHO1 in Growth Plate Homeostasis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023
    Article
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Janos SchmidtInstitute of Biochemistry and Medical Chemistry, Medical School, University of Pécs, Pécs, Hungary.
Béla KajtárDepartment of Pathology, Medical School, University of Pécs, Pécs, Hungary.
Kata JuhászInstitute of Biochemistry and Medical Chemistry, Medical School, University of Pécs, Pécs, Hungary.
Mária PéterInstitute of Biochemistry, Biological Research Center, Szeged, Hungary.
Tamás JáraiDepartment of Oto-Rhino-Laryngology, Medical School, University of Pécs, Pécs, Hungary.
András BuriánDepartment of Oto-Rhino-Laryngology, Medical School, University of Pécs, Pécs, Hungary.
László KereskaiDepartment of Pathology, Medical School, University of Pécs, Pécs, Hungary.
Imre GerlingerDepartment of Oto-Rhino-Laryngology, Medical School, University of Pécs, Pécs, Hungary.
Tamás TornóczkiDepartment of Pathology, Medical School, University of Pécs, Pécs, Hungary.
Gábor BaloghInstitute of Biochemistry, Biological Research Center, Szeged, Hungary.
László VíghInstitute of Biochemistry, Biological Research Center, Szeged, Hungary.
Lászó Márk *Institute of Biochemistry and Medical Chemistry, Medical School, University of Pécs, Pécs, Hungary.
Zsolt Balogi *Institute of Biochemistry and Medical Chemistry, Medical School, University of Pécs, Pécs, Hungary.
University of Pecs · HUInstitute of Biochemistry · HUHUN-REN Szegedi Biológiai Kutatóközpont · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. To improve pre- and post-operative diagnosis and prognosis novel molecular markers are desirable. Here we used MALDI imaging mass spectrometry (IMS) and immunohistochemistry (IHC) to seek tumor specific expression of proteins and lipids in HNSCC samples. Among low molecular weight proteins visualized, S100A8 and S100A9 were found to be expressed in the regions of tumor tissue but not in the surrounding healthy stroma of a post-operative microdissected tissue. Marker potential of S100A8 and S100A9 was confirmed by immunohistochemistry of paraffin-embedded pathological samples. Imaging lipids showed a remarkable depletion of lysophosphatidylcholine species LPC[16:0], LPC[18:2] and, in parallel, accumulation of major glycerophospholipid species PE-P[36:4], PC[32:1], PC[34:1] in neoplastic areas. This was confirmed by shotgun lipidomics of dissected healthy and tumor tissue sections. A combination of the negative (LPC[16:0]) and positive (PC[32:1], PC[34:1]) markers was also applicable to uncover tumorous character of a pre-operative biopsy. Furthermore, marker potential of lysophospholipids was supported by elevated expression levels of the lysophospholipid degrading enzyme lysophospholipase A1 (LYPLA1) in the tumor regions of paraffin-embedded HNSCC samples. Finally, experimental evidence of 3D cell spheroid tests showed that LPC[16:0] facilitates HNSCC invasion, implying that HNSCC progression

Indexed as

Imaging mass spectrometrylipid tumor markerS100A8S100A9tumor marker

Identifiers

PMID32733643
PMCPMC7367650
OpenAlexW3042601791

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.