ArticleOncotarget2020
Development and comprehensive characterization of porcine hepatocellular carcinoma for translational liver cancer investigation.
Article in Oncotarget, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 32 citations in OpenAlex.
- Characterization of inflammatory pseudotumors in a large animal model of liver cancer.Animal models and experimental medicine · 2026Article
- Development of a high-grade glioma preclinical surgery model using an inducible KRAS/TP53 Oncopig.Frontiers in oncology · 2026Article
- Single and multi-omic characterization of a porcine model of ethanol-induced hepatic fibrosis.Epigenetics · 2025Article
- Development of a whole-exome sequencing kit to facilitate porcine biomedical research.Genome biology · 2025Article
- Optimizing microwave ablation planning with the ablation success ratio.Scientific reports · 2025Article
- Development of a genetically tailored implantation hepatocellular carcinoma model in Oncopigs by somatic cell CRISPR editing.Disease models & mechanisms · 2025Article
- Analysis of growth rate, haematologic, and biochemical parameters of Oncopigs.International journal of veterinary science and medicine · 2025Article
- Volumetric CT Assessment of In Situ Induced Hepatic Lesions in a Transgenic Swine Model.Life (Basel, Switzerland) · 2024Article
- Genetic engineering drives the breakthrough of pig models in liver disease research.Liver research (Beijing, China) · 2024Review
- Magnetic Resonance Elastography for Staging Liver Fibrosis in the Oncopig.Diagnostics (Basel, Switzerland) · 2024Article
- Pigs: Large Animal Preclinical Cancer Models.World journal of oncology · 2024Review
- Benefits and opportunities of the transgenic Oncopig cancer model.Trends in cancer · 2024Article
- Swine global genomic resources: insights into wild and domesticated populations.Mammalian genome : official journal of the International Mammalian Genome Society · 2023Article
- Advances in experimental animal models of hepatocellular carcinoma.Cancer medicine · 2023Review
- Preclinical studies performed in appropriate models could help identify optimal timing of combined chemotherapy and immunotherapy.Frontiers in immunology · 2023Review
- The Oncopig as an Emerging Model to Investigate Copper Regulation in Cancer.International journal of molecular sciences · 2022Review
- Three-dimensional assessment of vascular cooling effects on hepatic microwave ablation in a standardized ex vivo model.Scientific reports · 2022Article
- Current Challenges in Image-Guided Magnetic Hyperthermia Therapy for Liver Cancer.Nanomaterials (Basel, Switzerland) · 2022Review
- Conventional versus drug-eluting embolic transarterial chemoembolization with doxorubicin: comparative drug delivery, pharmacokinetics, and treatment response in a rabbit VX2 tumor model.Drug delivery and translational research · 2022Article
- Swine models for translational oncological research: an evolving landscape and regulatory considerations.Mammalian genome : official journal of the International Mammalian Genome Society · 2022Review
Corrections and comments
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Authors and funding
22 authors at 4 institutions in 1 country.
Funding
Abstract
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. New animal models that faithfully recapitulate human HCC phenotypes are required to address unmet clinical needs and advance standard-of-care therapeutics. This study utilized the Oncopig Cancer Model to develop a translational porcine HCC model which can serve as a bridge between murine studies and human clinical practice. Reliable development of Oncopig HCC cell lines was demonstrated through hepatocyte isolation and Cre recombinase exposure across 15 Oncopigs. Oncopig and human HCC cell lines displayed similar cell cycle lengths, alpha-fetoprotein production, arginase-1 staining, chemosusceptibility, and drug metabolizing enzyme expression. The ability of Oncopig HCC cells to consistently produce tumors
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.