ArticleFrontiers in immunology2020
Tryptophan Catabolism as Immune Mechanism of Primary Resistance to Anti-PD-1.
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Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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0cells of the map it votes in
39citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 46 citations in OpenAlex.
- Beyond the primary site: Molecular insights and clinical implications of cancer metastatic overlap between lung and urological organ cancers (Review).Molecular medicine reports · 2026Review
- Spleen Metabolome Reveals Immune-Mediated Responses Modulated by Onion Peel Extract inMicroorganisms · 2026Article
- Gut microbiota and cancer immunotherapy: from dysbiosis to personalized immune checkpoint blockade optimization.Folia microbiologica · 2026Review
- Impact of immunochemotherapy administration sequence on overall survival in advanced esophageal and gastric cancers: a propensity score-matched multicenter analysis.Cancer immunology, immunotherapy : CII · 2026Observational
- Spatially resolved tryptophan-kynurenine niches in HNSCC: immunometabolic microdomains and therapeutic implications.Frontiers in immunology · 2026Review
- Tumor-immune metabolic tug-of-war: from immune escape to targeting metabolic rewiring in cancer therapy.Frontiers in cell and developmental biology · 2026Review
- Pan-cancer biomarkers of immune therapy resistance: mechanisms and clinical translation.Frontiers in cell and developmental biology · 2026Review
- Intratumoral Microbiota in Lung Cancer: Emerging Roles in TME Modulation and Immunotherapy Response.International journal of molecular sciences · 2025Review
- Review
- The regulatory role and mechanism of energy metabolism and immune response in head and neck cancer.Genes & diseases · 2025Review
- Immunotherapy resistance in non-small cell lung cancer: from mechanisms to therapeutic opportunities.Journal of experimental & clinical cancer research : CR · 2025Review
- Improving IL12 immunotherapy in glioblastoma by targeting the long noncoding RNA INCR1.Journal of neuro-oncology · 2025Article
- Mechanisms of primary resistance to immune checkpoint inhibitors in NSCLC.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Review
- Targeting the Kynurenine Pathway: A Novel Approach in Tumor Therapy.Expert reviews in molecular medicine · 2025Review
- A Novel Liquid Chromatography-Tandem Mass Spectrometry Method to Quantify Tryptophan and Its Major Metabolites in Serum to Support Biomarker Studies in Patients with Cancer Undergoing Immunotherapy.Molecules (Basel, Switzerland) · 2024Article
- Targeting metabolism to enhance immunotherapy within tumor microenvironment.Acta pharmacologica Sinica · 2024Review
- FSTL3 promotes tumor immune evasion and attenuates response to anti-PD1 therapy by stabilizing c-Myc in colorectal cancer.Cell death & disease · 2024Article
- Targeting the aryl hydrocarbon receptor (AhR) with BAY 2416964: a selective small molecule inhibitor for cancer immunotherapy.Journal for immunotherapy of cancer · 2023Article
- Integration of metabolomics and machine learning revealed tryptophan metabolites are sensitive biomarkers of pemetrexed efficacy in non-small cell lung cancer.Cancer medicine · 2023Article
- A Prognostic Model of Head and Neck Cancer Based on Amino Acid Metabolism-Related Signature and Its Implication for Immunosuppressive Microenvironment.International journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 1 country.
Andrea BotticelliDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Silvia MeziDepartment of Radiological, Oncological and Pathological Sciences, Faculty of Medicine and Dentistry, Sapienza University of Rome, Rome, Italy.
Giulia PomatiDepartment of Radiological, Oncological and Pathological Sciences, Faculty of Medicine and Dentistry, Sapienza University of Rome, Rome, Italy.
Bruna CerbelliDepartment of Radiological, Oncological and Pathological Sciences, Faculty of Medicine and Dentistry, Sapienza University of Rome, Rome, Italy.
Edoardo CerbelliDepartment of Radiological, Oncological and Pathological Sciences, Faculty of Medicine and Dentistry, Sapienza University of Rome, Rome, Italy.
Michela RobertoDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Raffaele GiustiMedical Oncology Unit, Sant'Andrea Hospital of Rome, Rome, Italy.
Alessio CortelliniMedical Oncology Unit, San Salvatore Hospital, L'Aquila, Italy.
Luana LionettoExperimental Immunology Laboratory, Biochemistry Laboratory, IDI-IRCCS FLMM, Rome, Italy.
Simone ScagnoliDepartment of Medical and Surgical Sciences and Translational Medicine, Sapienza University of Rome, Rome, Italy.
Ilaria Grazia ZizzariDepartment of Experimental Medicine, Faculty of Medicine and Dentistry, Sapienza University of Rome, Rome, Italy.
Marianna NutiDepartment of Experimental Medicine, Faculty of Medicine and Dentistry, Sapienza University of Rome, Rome, Italy.
Maurizio SimmacoAdvanced Molecular Diagnostics Unit, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.
Paolo MarchettiDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Sapienza University of Rome · ITAzienda Ospedaliera Sant'Andrea · ITCTO Andrea Alesini · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITSan Salvatore Hospital · IT
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
AgedAged, 80 and overBiomarkers, TumorCell Line, TumorDrug Resistance, NeoplasmFemaleHumansImmune Checkpoint InhibitorsKynurenineMaleMiddle AgedNeoplasm GradingNeoplasmsNeoplasm StagingOdds RatioPrognosisBiomarkers, TumorImmune Checkpoint InhibitorsKynurenineProgrammed Cell Death 1 ReceptorTryptophananti-PD-1indoleamine-2,3-dioxygenasekynureninetryptophan metabolismtumor immunity
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What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.