ReviewFrontiers in psychiatry2020
A Predictive Coding Perspective on Mismatch Negativity Impairment in Schizophrenia.
Review in Frontiers in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Complex Pattern Mismatch Negativity as a Potential Indicator of Psychosis Across all Phases of Illness: A Meta-Analysis.Clinical EEG and neuroscience · 2025Pooled it
- Visuomotor mismatch EEG responses over occipital cortex of freely moving human subjects.eLife · 2026Article
- Strong connections of locally clustered neurons in the upper-layer cortex underlie schizophrenia-related auditory deviance detection.Science advances · 2026Article
- Errors or Adaptations? A Critical Review of Predictive Processing in Psychiatry.Behavioral sciences (Basel, Switzerland) · 2026Review
- Attenuated inferred-sensory mismatch during masked face recognition in schizophrenia.Frontiers in psychiatry · 2026Article
- The predictive processing embodied in brain conditions: the role of precision.Frontiers in psychology · 2026Article
- Trust your gut: the neuro-gastroenteric mechanics of prediction and expectation.Frontiers in human neuroscience · 2026Article
- Empirically Integrating the Evidence for Different Predictive Coding Components Using Auditory False Perception.Human brain mapping · 2025Article
- Synaptic Function and Sensory Processing in ZDHHC9-Associated Neurodevelopmental Disorder: A Mechanistic Account.The European journal of neuroscience · 2025Article
- Neurocomputational Mechanisms of Sense of Agency: Literature Review for Integrating Predictive Coding and Adaptive Control in Human-Machine Interfaces.Brain sciences · 2025Review
- Traveling waves shape neural population dynamics enabling predictions and internal model updating.bioRxiv : the preprint server for biology · 2024Article
- A comparison of visual and acoustic mismatch negativity as potential biomarkers in schizophrenia.Scientific reports · 2024Article
- RDoC Framework Through the Lens of Predictive Processing: Focusing on Cognitive Systems Domain.Computational psychiatry (Cambridge, Mass.) · 2024Review
- Habituation, Adaptation and Prediction Processes in Neurodevelopmental Disorders: A Comprehensive Review.Brain sciences · 2023Review
- Working memory and sensory memory in subclinical high schizotypy: An avenue for understanding schizophrenia?The European journal of neuroscience · 2023Review
- Early auditory processing dysfunction in schizophrenia: Mechanisms and implications.Neuroscience and biobehavioral reviews · 2023Review
- Memory-Based Prediction Deficits and Dorsolateral Prefrontal Dysfunction in Schizophrenia.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- The role of the salience network in cognitive and affective deficits.Frontiers in human neuroscience · 2023Review
- Markov chains as a proxy for the predictive memory representations underlying mismatch negativity.Frontiers in human neuroscience · 2023Article
- Correlation of motor-auditory cross-modal and auditory unimodal N1 and mismatch responses of schizophrenic patients and normal subjects: an MEG study.Frontiers in psychiatry · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mismatch negativity (MMN) is a widely used biological marker for schizophrenia research. Previous studies reported that MMN amplitude was reduced in schizophrenia and that reduced MMN amplitude was associated with cognitive impairments and poor functional outcome in schizophrenia. However, the neurobiological mechanisms underlying the reduced MMN amplitude remain unclear. Recent studies suggest that reduced MMN amplitude may reflect altered predictive coding in schizophrenia. In this paper, we reviewed MMN studies that used new paradigms and computational modeling to investigate altered predictive coding in schizophrenia. Studies using the roving oddball paradigm and modified oddball paradigm revealed that the effects of conditional probability were impaired in schizophrenia. Studies using omission paradigms and many-standards paradigms revealed that prediction error, but not adaptation, was impaired in schizophrenia. A study using a local-global paradigm revealed that hierarchical structures were impaired at both local and global levels in schizophrenia. Furthermore, studies using dynamic causal modeling revealed that neural networks with hierarchical structures were impaired in schizophrenia. These findings indicate that altered predictive coding underlies the reduced MMN amplitude in schizophrenia. However, there are several unsolved questions about optimal procedures, association among paradigms, and heterogeneity of schizophrenia. Future studies using several paradigms and computational modeling may solve these questions, and may lead to clarifying the pathophysiology of schizophrenia and to the development of individualized treatments for schizophrenia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.