Evidence map›Paper›PMID 32733265›Full record

ReviewFrontiers in physiology2020

Integrating Ultra-Weak Photon Emission Analysis in Mitochondrial Research.

Roeland Van Wijk, Eduard P A Van Wijk, Jingxiang Pang, Meina Yang, Yu Yan, Jinxiang Han

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Chemiexcitation in Ex Vivo Porcine Skin Model.Pigment cell & melanoma research · 2025
    Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Non-chemical signalling between mitochondria.Frontiers in physiology · 2023
    Article
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Roeland Van WijkMeluna Research, Department of Biophotonics, Geldermalsen, Netherlands.
Eduard P A Van WijkMeluna Research, Department of Biophotonics, Geldermalsen, Netherlands.
Jingxiang PangKey Laboratory for Biotech-Drugs of National Health Commission, Shandong Medicinal Biotechnology Center, Jinan, China.
Meina YangKey Laboratory for Biotech-Drugs of National Health Commission, Shandong Medicinal Biotechnology Center, Jinan, China.
Yu YanMeluna Research, Department of Biophotonics, Geldermalsen, Netherlands.
Jinxiang HanKey Laboratory for Biotech-Drugs of National Health Commission, Shandong Medicinal Biotechnology Center, Jinan, China.
National Health and Family Planning Commission · CNShandong First Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Once regarded solely as the energy source of the cell, nowadays mitochondria are recognized to perform multiple essential functions in addition to energy production. Since the discovery of pathogenic mitochondrial DNA defects in the 1980s, research advances have revealed an increasing number of common human diseases, which share an underlying pathogenesis involving mitochondrial dysfunction. A major factor in this dysfunction is reactive oxygen species (ROS), which influence the mitochondrial-nuclear crosstalk and the link with the epigenome, an influence that provides explanations for pathogenic mechanisms. Regarding these mechanisms, we should take into account that mitochondria produce the majority of ultra-weak photon emission (UPE), an aspect that is often ignored - this type of emission may serve as assay for ROS, thus providing new opportunities for a non-invasive diagnosis of mitochondrial dysfunction. In this article, we overviewed three relevant areas of mitochondria-related research over the period 1960-2020: (a) respiration and energy production, (b) respiration-related production of free radicals and other ROS species, and (c) ultra-weak photon emission in relation to ROS and stress. First, we have outlined how these research areas initially developed independently of each other - following that, our review aims to show their stepwise integration during later stages of development. It is suggested that a further stimulation of research on UPE may have the potential to enhance the progress of modern mitochondrial research and its integration in medicine.

Indexed as

agingdiagnosismitochondriareactive oxygen speciesstressultra-weak photon emission

Identifiers

PMID32733265
PMCPMC7360823
OpenAlexW3041755811

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.