Evidence map›Paper›PMID 32733232›Full record

ArticleFrontiers in aging neuroscience2020

Corticomotor Plasticity Predicts Clinical Efficacy of Combined Neuromodulation and Cognitive Training in Alzheimer's Disease.

Anna-Katharine Brem, Riccardo Di Iorio, Peter J Fried, Albino J Oliveira-Maia, Camillo Marra, Paolo Profice, Davide Quaranta, Lukas Schilberg, Natasha J Atkinson, Erica E Seligson and 2 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01504958 (Effects of a Combined TMS and Cognitive Training in Alzheimer Patients), which is not on this map. Cited by 35 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 7 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01504958 nacompletednot on this map

Effects of a Combined TMS and Cognitive Training in Alzheimer Patients: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Study

TypeinterventionalSponsorBeth Israel Deaconess Medical CenterRan2010 to 2015Enrolled22ConditionsAlzheimer's DiseaseArmsRepetitive Transcranial Magnetic Stimulation (rTMS), NICE Cognitive Training
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 7 syntheses or guidelines pooled it, 63 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 6 countries.

Anna-Katharine BremBerenson-Allen Center for Noninvasive Brain Stimulation, Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States.
Riccardo Di IorioDepartment of Geriatrics, Neurosciences and Orthopaedics, Polyclinic A. Gemelli Foundation-IRCCS, Rome, Italy.
Peter J FriedBerenson-Allen Center for Noninvasive Brain Stimulation, Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States.
Albino J Oliveira-MaiaChampalimaud Research and Clinical Centre, Champalimaud Centre for the Unknown, Lisbon, Portugal.
Camillo MarraDepartment of Geriatrics, Neurosciences and Orthopaedics, Polyclinic A. Gemelli Foundation-IRCCS, Rome, Italy.
Paolo ProficeDepartment of Geriatrics, Neurosciences and Orthopaedics, Polyclinic A. Gemelli Foundation-IRCCS, Rome, Italy.
Davide QuarantaDepartment of Geriatrics, Neurosciences and Orthopaedics, Polyclinic A. Gemelli Foundation-IRCCS, Rome, Italy.
Lukas SchilbergBerenson-Allen Center for Noninvasive Brain Stimulation, Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States.
Natasha J AtkinsonBerenson-Allen Center for Noninvasive Brain Stimulation, Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States.
Erica E SeligsonBerenson-Allen Center for Noninvasive Brain Stimulation, Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States.
Paolo Maria RossiniDepartment of Neuroscience and Neurorehabilitation, IRCCS San Raffaele, Rome, Italy.
Alvaro Pascual-LeoneHinda and Arthur Marcus Institute for Aging Research and Center for Memory Health, Hebrew SeniorLife, Boston, MA, United States.
Agostino Gemelli University Polyclinic · ITBerenson Allen Center for Noninvasive Brain Stimulation · USBeth Israel Deaconess Medical Center · USIstituti di Ricovero e Cura a Carattere Scientifico · ITCentro Hospitalar de Lisboa Ocidental · PTInstitut Guttmann · ESIstituto di Ricovero e Cura a Carattere Scientifico San RaffaeleUniversity of Oxford · GB

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
Transcranial Direct Current Stimulation and Robotic Training in Chronic StrokeR01HD069776 · NICHD · WINIFRED MASTERSON BURKE MED RES INST · PI EDWARDS, DYLAN JAMES · 2012 to 2016
$3.2M
Cortical connectivity, physiology, and response to stimulation in human epilepsyR01NS073601 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CHANG, BERNARD S. · 2011 to 2015
$1.9M
Role of functional brain connectivity on efficacy of TMS for depressionR21MH099196 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PASCUAL-LEONE, ALVARO · 2013 to 2014
$491k
Cortical plasticity in type II diabetes mellitusR21NS082870 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PASCUAL-LEONE, ALVARO · 2013 to 2014
$490k
Transcranial Stimulation in Spino-Cerebellar AtaxiaR21NS085491 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PASCUAL-LEONE, ALVARO · 2013 to 2014
$469k
NCRR NIH HHS UL1 RR025758NICHD NIH HHS R01 HD069776NIMH NIH HHS R21 MH099196NINDS NIH HHS R01 NS073601NINDS NIH HHS R21 NS082870NINDS NIH HHS R21 NS085491
6 · The paper itself

Abstract

objectiveTo investigate the efficacy of repetitive transcranial magnetic stimulation (rTMS) combined with cognitive training for treatment of cognitive symptoms in patients with Alzheimer's disease (AD). A secondary objective was to analyze associations between brain plasticity and cognitive effects of treatment.

methodsIn this randomized, sham-controlled, multicenter clinical trial, 34 patients with AD were assigned to three experimental groups receiving 30 daily sessions of combinatory intervention. Participants in the real/real group (

resultsAt baseline, patients with AD had worse cognition, cerebral atrophy, and TMS measures of cortico-motor reactivity, excitability, and plasticity than HC. The real/real group showed significant cognitive improvement compared to the sham/sham, but not the real/sham group. TMS-induced plasticity at baseline was predictive of post-intervention changes in cognition, and was modified across treatment, in association with changes of cognition.

interpretationCombined rTMS and cognitive training may improve the cognitive status of AD patients, with TMS-induced cortical plasticity at baseline serving as predictor of therapeutic outcome for this intervention, and potential mechanism of action. CLINICAL

trial registrationwww.ClinicalTrials.gov, identifier NCT01504958.

Indexed as

Alzheimer’s diseaseclinical trialcognitive trainingcombinatory interventionplasticityrandomized controlledtranscranial magnetic stimulation

Identifiers

PMID32733232
PMCPMC7360860
OpenAlexW3035183428

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.