ArticleFrontiers in neuroscience2020
Is Ross Syndrome a New Type of Synucleinopathy? A Brief Research Report.
Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Complete heart block in Ross syndrome.HeartRhythm case reports · 2023Article
- Concurrence of Hyperhidrosis and Hypohidrosis in Ross Syndrome.Clinical medicine & research · 2023Article
- Article
- Clinical presentation and autonomic profile in Ross syndrome.Journal of neurology · 2021Article
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
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Abstract
Ross syndrome (RS) is a rare peripheral autonomic system disorder characterized by tonic pupil, hyporeflexia, and segmental anhidrosis. Neuropathological studies show that RS results from the selective cholinergic nerve degeneration. However, the cause and underlying mechanisms are largely unknown. Here, we show α-synuclein accumulation in the autonomic nerve terminals in the lesser curvature of stomach of patients with RS. In addition, immunohistochemical findings demonstrate that a dominant degeneration of cholinergic fibers is exhibited in patients with RS, while main degeneration of adrenergic fibers is demonstrated in patients with pure autonomic failure in their gastrointestinal and urinary system. Our study suggests that RS belongs to α-synucleinopathies. Moreover, our findings indicate that adrenergic nerves and cholinergic nerves are not equally damaged in different types of pure autonomic dysfunctions.
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