Trial reportScientific reports2020
The indirect effect of peer problems on adolescent depression through nucleus accumbens volume alteration.
Trial report in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- A systematic review of the association between biological markers and environmental stress risk factors for adolescent depression.Journal of psychiatric research · 2021Pooled it
- Depression in Chinese adolescents: prevalence, symptoms, risk factors, affected brain, diagnosis, and interventions.Frontiers in psychology · 2026Review
- The impact of negative cognitive bias on NSSI: mediating non-adaptive cognitive emotion regulation strategies.BMC nursing · 2024Article
- Age-dependent alterations in the coordinated development of subcortical regions in adolescents with social anxiety disorder.European child & adolescent psychiatry · 2024Article
- Social threat, fronto-cingulate-limbic morphometry, and symptom course in depressed adolescents: a longitudinal investigation.Psychological medicine · 2023Article
- Prediction of Diagnosis and Treatment Response in Adolescents With Depression by Using a Smartphone App and Deep Learning Approaches: Usability Study.JMIR formative research · 2023Article
- Aging in nucleus accumbens and its impact on alcohol use disorders.Alcohol (Fayetteville, N.Y.) · 2023Review
- Postnatal maternal distress, infant subcortical brain macrostructure and emotional regulation.Psychiatry research. Neuroimaging · 2023Article
- Si-Ni-San alleviates early life stress-induced depression-like behaviors in adolescence via modulating Rac1 activity and associated spine plasticity in the nucleus accumbens.Frontiers in pharmacology · 2023Article
- The association between peer-victimisation and structural and functional brain outcomes: A systematic review.JCPP advances · 2022Article
- Neurobiological correlates of the social and emotional impact of peer victimization: A review.Frontiers in psychiatry · 2022Review
- Integrative Brain Dynamics in Childhood Bullying Victimization: Cognitive and Emotional Convergence Associated With Stress Psychopathology.Frontiers in integrative neuroscience · 2022Review
- Dialectical Thinking Is Linked With Smaller Left Nucleus Accumbens and Right Amygdala.Frontiers in psychology · 2022Article
- Amygdala size varies with stress perception.Neurobiology of stress · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Literature suggests that neurobiological factors such as brain structure play an important role in linking social stress with depression in adolescence. We aimed to examine the role of subcortical volumetric alteration in the association between peer problems as one type of social stress and adolescent depression. We hypothesized that there would be indirect effects of peer problems on adolescent depression through subcortical volumetric alteration. Seventy eight adolescents with major depressive disorder (MDD) (age mean [SD] = 14.9 ± 1.5, 56 girls) and 47 healthy controls [14.3 ± 1.4, 26 girls]) participated in this study. High-resolution structural T1 images were collected using the Siemens 3T MR scanner. Subcortical volumes were segmented using the Freesurfer 6.0 package. Peer problems were assessed using the Peer-Victimization Scale and the Bullying-Behavior Scale. There was a significant indirect effect of peer problems on adolescent depression through nucleus accumbens (NAcc) volume alteration, but not through the amygdala and hippocampal volumes. This result supported our model, which stated that peer problems have indirect effects through subcortical volumetric alteration (i.e., increased NAcc volume) on adolescent depression. Our finding suggests that altered NAcc volume may serve as a pathway, through which peer problems as one type of social stressor contribute to adolescent depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.